ࡱ>   Fed_}ΩJFIF,,C     C    " }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?5FOiHJ` 2i_>?c ߈?эXAaWsq\'b~ GEQ 2i_[q4O| 2iG,/ ɤt_U~n>E?ϕ?sax[M#Koxn8 $qFxy'ҿ S^=# IRW.*JZ~E矡WO ?ھ*բl`< ?4AHnu!J.svK;Z k㷅ZI\*&7.H[9f-^Bܪ^8' گ[<7>"J[p7/ S' =+8Y?C1\QhEe~ <=2މuTW>߶}ǚv}B?=EoX!NRzNYԮ˅kI}xEћSʩ~~_>-xK/jٵl],W?{Kƺ7Gm-EQ:lE)o'+ }Ϡq%M2zk~>Ϭ[{L]mnc8xf{ ȭ}؏o\DGQJvٛf/,Sl_3'e?:/*XH3}Mꋸ+~ GEQ ¿2_{q4}Qw}XH?bxW]#q4n>.O| ¿2G,O ˤt_U~>E?ϕ?wtz隕"ǙY]3g ? jI-,?}\U!'[aajѴQEfz!EPE~dT~/xſ YO:<`5T` 'Ҿ'?a5Oƿ=nZ>{>2UQQ|en3Sn?>3Sn97?Hhߊ L%xPӮCcťֵq$SFӠdu/R  ?q袊((((((((((( >+C5h5싓g?vL} |⿂;k"35ڋRq%~׈~j?'ZR-Oݮo*K'-VfW涾V~x;/Z~rŮOAGV@=uOY+7z ;vE!v5f3ƚ<kZd1]NDFREy/aSh5WKme%ЂȈkaPu;O,m_~1ev>>٤XtDŽIR~9ߎ>M5=W&f^<3aQKdɧ.SC]/#7S[j_h.Mnr_ - "d]" T~i\goƻ0(((((((((((((((((((((((((((((((((7>\Z~j_Ч]/SNcJ_[Ox]дI+;#E ‚p3]~.R\H"ֵ{hbpFO`ks_85xX)xUePHf72 1'vO$i'q6>* 4|G^ǧeHxDQ'H[]+O m\D -{:,n!oOоO݆ZxMSĐkimĶNHK1'i~ϊk7u]n~K$$[BgهǟN-36pc[>x%tۡ|HߊN@2U?>2U9so ~:Ӽ1xsU.otRk"I${Ns?[O>h:.tIXnʙ˙9H?C_2"Qj*KGu^Is"F `,2O~5?ͼ ]/zVGQEQEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP_QOǿ4?ŦyǯA]̜gw:\h3P#EIY_|A`-c?h f$όA?(յGS<9#WrJi<ݟG8س/[ԭ^QZQ@Q@Q@Q@Q@Q@Q@Q@Rh>6ӿ?g{v񯈢T 42qF\g5SOV:GH?]3PP0dHi_~;Z&Kn!X'G!HUPp׵ w-c:\[\^) TsrJV5˟Ú^Eޡ[15f_[faEPEPEPEPGaՁ[?{n?cV{c/VQ_O ˛{z&z5: Bu''sYԚfwf5egktW(_O<+[o"P xWEs}j=T32{-?J\B3y_>W}o{c_ [HCqoۤ:+ AOipju#7UhٝVu/ hZN}L4R k?EmE]UM~Gȱ2ialy:F8G?!⋭ĺp~5숽G`+kOočW3[[>\cO=뀯b%Myg 1v]QE|Q^c)R[8;M]GT8Ā/ xYծ;%?=XJ!gqظ]ޟO+*o'Ya]X˓yL;WwV^fV/}vBgeN ;߱?S>.~ɟ~ -ޯ"5_ݴCoDHQ>רWӟmU?Z? 0u#?|_yxҘ+5?Z>}*Z+C;YiߺO#e9߅3R]ۋYbTJ 1_6VKOxƺΉo-A$hqRNTQEQ!EPEPEPEPEPEPEPEPEPEPEP^!mɨMDk?m5[ks}X~\_V[QEhbQEQEQEQEQEQEQEw'Ti~&-M{9g$ 1Fp9!x~n4CkiVH#(*j_O&kJ-V\i[Θ +G6mЮu/BvD7R\1'h:Ց cXԂ8#H݂E}%E+!݅QLAEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP_~4Ɩ|#!}vJd=U`7_;kcji~"N:*_2~"od5}Jnne<n\RVyky!C$ǒk_ -,Ҽ5Q\3ϔ0Ih=Wh |xW@.%d嶨{9$$hŠ(#~4>]{/FEqcngyPpO|k%3ZxxoDiG)~:(}OG@2\JKJ*Z~ >vz]GMZFԞ䞥I6 k-ؾ{m1ɲleak=w GmdVҌo(d`+{>H{ .7F Ċ~=TrH' ¿<ح_YPġ4UP0qbj8Unˡ5UtK-W~QE#(u*2=/e?z'{sN3Ȗ *w7͝ˌdIc )Vvw^L(p(ǟ'Nc%+l9蔮/HgE韗},J{NۚҾ Y5x8ES (ϡ ( ( ( ?sMK^^gNɷ|UWTIhz?#oظS|_w!.TOXg0zksYl~QT,?a?ƴ1>wMgjɭi-0^5pu~mM:ivӵk(o팫RtpÊA̓ؿ7YiSٿMgRjAi~ R s*5= W]PXDۣKdP  yƿ7㻋0O| 0r!r=wa<330M)m ϵhsIlWk+%'ƥ7rV?U(i/e}o V5ӂ`aE}Xz|7⛈5zĖ9W9, $V R~7/ }s?~ɞ)Ҽ1鷩sd(Pnc ]Ѣ?r?`??cľ.[m5tƟ < Acens_LW_H?6q-R~t۟|/LVV oY7:`¼ X>7k+Zy_Fx)YRp+o* keG*j<+}dܪ8Rw)5?痆\vk[3?ƓW:i^I rxrM>ty߅H ޺N'=W~+8xۖ9٦]`+oW+Edž#v ?i{@sk[W.{CwԻl㱸*=#Uf+~8xSl>&fCz^6+%AU>9g"gwm[j;FJ$8 po5ٛk=o4] H+{Wx{^𮽧k:]Z}wV9+p@57h? +e!|9"P:e? خ1 W3xP,L^8v4q8Q/7? \O-H4%iتVu ~e~ٿNG>yOk~ -ympGڴ'$c̏nP.|Oz/#_@ܩl~QEq?-|Oyx*|VtΙ4hxBUT0#,F{աk50g r}8{^ Qᖣn5}kN%րiw+pбaɯ߉ߋΙx3J̨U/R ʀ0 q#3w"_I㜮:#!lԴI _G0xo&O{) ~ 8# O%i; N=G?F}k;՘QEp>.h>k4[ Mrľlx&Wǟ3a .VNuX#8dd[;mgm'$G"Ʒw<Ϣ#ǭ|7~<@|[ƹlEZ J~.rI'??.G(6Е}mB9ݑoc[$ EJ|\|Fxu_ʺX kTj~\[9V_n ~s:O4k]#Cmt.pYBE*UmNk[xRC2GS>O7Vuo!ΣAg]Ywf20c_V,oGx:/Gu^Is"F-@I c'־^~Ś_-#xX^[:\Cv3J!~EliոzC3chq??mu= .IFWI *?(=kKɩ}⇋Ĺ򵛈O?_ c E4Nypǹ.3teFLȥCG4|c)"}ԃSf_2]߅Q/ K5[2 i?SǨ=+sY/R1M6YmMSEIjlA+ ߳k%֖.ۉ YHd$u(OƋuhӵ8adaa+ AI; E 9ֆAUuMRDӮo ,lm2ss 8 f<sR^^AZOuu2[@$JU $9ۧ?h_xkwsY|:1FJMuۑC`nJ CjV܌aA_oX[;jp`Ӽ5l oK7I<_M7;dRilo琠qe%=~Z7XlP./PWmݥy ;*ueD}fl(d"+#V+ZEo![M`q] U0=3ou㭶>ZS@8t>qպ(EYQEQE'+ɡ2ɧ?珆\r_5 h~+HS[Ѭ5$ Wp8Jڃ_mݟt+[<9$SæV A*]M_?.;_M~ǿPMO?hɠݢi_?(KTg1^'~! `5fc53[E R7zSvh>E#^JUtYamVQA eRG|>$w^ {f3q}whFT~U]kf "5ˌ't=s_7Wӭ5M:vMiy >Vds%:xos5[ba_? x<˂#o$?xW_Pzogw 6v?)Csp*H Tݢ-|=1R+kh -o&l}f\=^2UIC)5 ZͫAsu4vСI`KxVnn_ MZ"QIǧFOPƺ(ߋm<Ꮗw2蓮5A2gP|/<“b T=-eεm&:Bn@HǠhOqGWB[_,n>GlC>,k~ri _tV<(2K1#qJ^^RnDi@tyϼFsy9{W~wգQ KgZC+E,DQ ¶ p kZ\iezHefaPXu8+$5O.i6+;y3>QI^cf~m?\Og^ₛ4qV/O5m|Uywx"Kfl gAnlm`{Wo%^;ՌR}Ma5$pw$ 5nVyŏ*//m< 1!!!Yn 4OxeCR|Q9u+??IoxC76sp]:o/[oztyPz[ǣ$TG6es.7)_?ZuNtE8YW[no,gp1ApA#ş&O>mI '{P/E1KOq &B=ہ"C~:|E/ÖlI[?-U=2} ; AmN_ź6dMXbIqk| sѼ >]M=ܱ$ٲSaR|b.|jEcWW-4(%pA{j:n*,;wO/ů:֧ x]Y]ivuRLߌ#p8L=*uEH7=3ױj:U skue%UkJ:?nxᦣ;LNSL) ٣yZEӹVaESQEQESy& :IӽO q.V0=5^kxO_O4E`|@"H|MI]Ծ .=3$௾kBO~ȟD f폩y$<+:lb (((?Wީ Emkm26MfϥxI|na W놳ž"kW:Fx+\^X, 2|#e/-Sw/"O,o-p/;IP jr[Xyxgk=|q+_eu3u8q~X Iʋzk &c}$$>d<0HfcMY|Bυ^/X4mwKs9TY(WO+_u?nt%SWY%e8?nGJ۫)][inf{}&[ 9+\Ϗ=l:f?=ψO ·>KYdv# DhٍK~3FږHϡU '-AhwGoC3"ulmHmm  (@U+?|)yΓt^CF;2GcN?9?g+Vm[໰IdpԦEc_.[/4v9P ^~$6 M`Zv1268܍+&'Uw~w|A1]6:^wcneݟˎgE|NdMr_ }s-ǃ&s$˦NKW$j .?X|5~7/ vW/ h~_ä4k !&2-B8z5I3VWgYV4KM@i)Y!G&n#,Bj7G(i/$Gyu83ݭU/ٟ _Lmj@%U@"dEKL`/a,ʸ-u/vwPV߮~֟Er|PRfO6U+wyqsq vX, r&\YO~|s|$Ỹ4 i ihvn&8"L#=r3W⿏<|8}nMܖwFb SOP{ K-4۟j n/SMM ߊWzjꚽ=ny?&M|}.,]&ad8ySà`UTJ 3l+S? x)k8.O!+?j/POj%Rp-~?9B'QX?;d-~~~$ռ_+x W5;gUR.e$9=/M_ُ=//i),ΤyRUR ӿ'Ïҩ-VD?kkm_67ۆ\l_>7c?ׯx;AgiǑ}Op3A_= |~?ol<)XCO9ʰ\ ?.;_m=j/~~NYxmCkݖl_n;WY)'RI#^*t_"vFXcc*̏1LrЅue-k[%?zv(kk'?tƷw=K8> 5 Sߏo|hD2ݸVe+5ǁ~~}: k1 ۇ=t'ڧV^f?jٹ!9 ^xdF ?]O('ڄ2xX4> LIGv\W쯋>|7Ƒ.xA6m{ՐcGPRşcsiw:If o1 )rFzԴI$~~<53E=:,'X|deOr ٿ񅜲,JУ'sh$`BN0G4L92";%bJ(((G |}߉_C6o84('&mCPl.oo&KkKhih,s_GC~?=9E!R,=$b{ /E݊J|qxķ_ t i P.okf8?v;>-ki:bLؖ@OWmt?u/o3uO̹*f+НGk C kHQaTJ6?  QCZ= O e,=V+ 5Υk] V"b+gsŸ<yi0}$}A"?h_ NMkEͻH:GjդAFc .R.Y*Â*~V-?j  ;䙿4 @^TꓹV ((-x/߈)i n0E$,5ͳ#W$lŁ*0 #|< quiYa%P4 za3 K%̢KOc0ٕI+ -m[՟S8si2ٖ&E}Ꮐcм>45iݤ`Y&V]? a0ݛ1[\ A|W??|ZxEχK*JƑ_@E9q 97/Zb_Z4ľSoMX%P>_3`bg  ~z=߇*#[OuI5.iwÏŏ~*jZ.0zᕁYH K_Hύ7zWu隭jV1qXr됯zf՘QEQEQEQEߴ?/_-j_M%z y$ WZI@zH8د?Z}GUf6{QEh`|W_~?5h.I h9w88Г >eޣ}:ZZB< j 3 տiw,>wt8X_ ŠMؤ{+/Q{qeN X"Kf!glz~ŋm+RYI[ %w|! _&6X YNP8ʁKIL\0oE,q @J6' këx:N?c0RGw* wLXF#ң`YVN_z]5?>ߋu+rkgDQǨσ_>!Ni4 ݢG89 ZG+jzkiPX]FAsneYXpA _K/ڪK%^Af Y?sف]Rw3j\o |E-Z=:>im|E׋5iM tUَ_o OGE-5\mƣ׻7@4}9 W4_i9";ǩ i![5g?*~- ]X~U -OL=ToRU/$.[|1'w~;:h~-4]&vigu''y&&mGcnO_8Uյ/z]\[ VO½;K4/hVskv[XxJ Rr maxeԫ#zĚ7ti~*NLeMoI]ŽJ8@Xe|@5hOs?]#gKkyh>}-ш2HX)v;A=+~֞9| M1ZKul0lۆ\lF%-~ [4`(?gnq S[g/= R~7/ ~~՟ <.%]^IiУ&+#W%'tZ~~?g>i?z&xj;)RI/<Ƒ1rķ:O x OH4VJGtrPzdW?fObXv7`> ˱@-c~`|&qgo?gQ&;UoDS= M$~|yq$?u-.&'l)[A AXK\WfЯ⏋EmnuyB}Fe? cJ/i /[2ͮ5W'0O^L7QdT$8pA?u?f BXxFż͹Tr u rNJ:Q_Jiρ <3dz_7ķ0IihȧYSe W)~S 3H|ir\KpUy@ Kuпl,ʼn.ĒI=Iٯ'췥|#IS_xo ̩q(S?w*C7BK`Vie|a|!o-?JGm?i̚F+ߧxMG͹HAw`x3i?MNqYB:-\H(ϔ[1TS<΁aWsw= WrFHUԕ*F5w/g@ontZ[LᑘY%pzaLm%'=/g/i>w !щ 6N@>+N13⏌4 > +X23>g' 2kK@XE4!K d9 k.Gof~qq3$]6wbrX$rj~K+ (m$+?.;[V 4]&HM{cn7 's_ /ZD?_ е;i] V85\&MZC 'u&4=suxJ%߉a&9 ,mqgy@GS]_?~Xh_ ] Oj2 s?I r ]S▦'0}>F3֐bI16cIߡJ۳㯈QO.e)͓VeO5->|QNOܸ?PAkS?~6,_x{OEŹbcI5⿵o-/4 񵵻ϧoʣ") lRGƟOt߉|]RMF(R+Ule`{[kM+-#Qn-n9YAAWm"4n)5qw}o⟆46ql) z.捀z .'*=71 ?Ƭ _^(c? |{a7u_YMB[A,{UPF?9S9+hw>:Kc74ñook=o0UU_1iPo; ~&f|<_x^ zM7<pTgRxm4mGq8&TW7;!?#h|1_.. Lsc+Q~9<;D}A.]mQ^߰6 me 4qK^<2?4x_K8utAXgv#"T_2g WRTi/آ+((((ǟ'Nc%+l9蔮/HgE韗},J{NۚҾ Y5x8ES (ϡ ( ( ( ?sMK^^gNɷ|UWTIhz?ï|Ig?_A-lȑ ($ 3+]_bL6nKWKWS>v6(zFwDWдSDJ#*؊f7,iK~:D>"[?"bf7,iK([\?O"~?~I޻:Nfgz 9I`?qSWJOAf6QZ+M|Y_6?U~$WLşcQED5Mğ5\%}_  IcUZWܵKb%WƟU5aOZ.4ɬ2j%W/?W~*ԭ1yҢ;Kc:(2?2L uSTDm|rʦݔ~J8;Gu~cosh~~4ı¶++cO5k٫C'4>NV8~xwb,)ͪo GK~~7Gbc[;X?uED5 l?l ~:6Ъ'[6 ) `;oZ?bh~F+F/p~&"OI֘-B5ȹ?? P.|Oznk-(1 (o@UhvCƣtN@ X[Gk:( 6d@|E~A ^&i6>~6[`{ӿi72Ҵ˭&KXmc>X#qzdjYqN7_GY-uKieR1Wx(Jm##^_b(c by86{F- Y?__S V]G.IK(lme$NjrQru}(x"4Eu@s/)~+u|; $ޜGT@*̎w› GFsim[y?iXĆ $ HVU8ָ+c|b_I}>ne-q9z(Š(AEgk$|/`ΧgGoHc_1Wϟ?~ySimb/~ m|vP$èq-FH+ۗj_FM}WP)|}P{_8/Zl?_7B6L%RmW3I?kVj l5_Le0ѧx?^%V4,>AxI#7ԆA=f6sI*5Cė RZJ\k?a"=Ngo z!?r:(b?0? ռ%I/Mcs'!'2{*qQ) ?.ZF;!~3Vosh~~f:hZ9״F#]RlOWm,e}lʎ5iV2j(b ( ڻM:zyO]&SŝCIށֿI\u_Og;nk-Ӛ(19/?,>,|5'585{-IaGX+uk:M΃_i/,{y=Qъ5*W'퓠GړmClmr|4,|P1Qϛ>\==  ZhP RMoemzX:"7袐U\+d-P˦ܣ)A`x&:rmgCp~\ZQEajW-O٭W%*!g+Zv.}#< |,M}W2UB[QEhbbDw'm_ԟ}_țׄ-HMB|O۴ N}al]AT$E  ",h@U~F ?5x |L+񆍠07?ُ;;76gn% WӢ_િ<(&Cmc#!Nha>1Cp|Ak^Եķw2N űƢFMZ*5 I y^@l~9_K;]#.j)aKp* ( C@οV6|@iF%> ,=&iFbݭx{$A^7YIe_, ^=@E{M|ZxEAϥMu̓Ь?(b ( ( / $/1/M_zWX?!~jOb'_M3]CK+qf?Tr|~|Lw+IL:iΧc{A+,$?'dH`?:_?N7P^}']u5u; oJ}痌4tګέ[\xz{ Q`QRd\dF1>ڟ|?g?Qyƨ~9WÚ)'O=G9H{tZ'&N-iMOO}(h8o7}2VE)Pᑔ}Awk??#} Tٲ>>,}_Md^)P$Qps4gz7F'!o&X,VIZMC7Buo?dU:GFy"΁ֳ{Gcر,u_4%1 Li0i߉%;+* ş*g`?bdhmCP Z/ҿ1kD/R:_&J^h[Ji?/$eC\~Оe>=|F=Lj ~ Լ0EUI8Wa >_¶qpit_e@-OrM= ?b'mU2k:O>9*?f7smkQI-o㿃PLѲ]{K~4:i޼"#.^L@+?n4 ډ^^tɥKgJn~ WOD_gjI7ȝ+\[QEhbQT}oNg]̱Fݘ(~[dmO|5 XF܅2?#_y{mn:[hQoa"/q_?kګĞ揨v:$7y$c!f =j[иsppAW]xsNZ2s_з&]/I"zUQVdQEQE|-7ßc[{+Tu(S~$Ww?Q/9Sj7S0) ~Xr;?O_R|_4Ii~ˍ#8za=q5_ O=7M 7ЦY5ZzEqs^E>ǩ?g?Qyƫ(ƿyOWmV->KDBI/I8=Os^E>Ǩ5SNzv Ezl CMQF ><7EmiƯ+?s^E>ǫ? )gK!4A@N6 iФ;(((kO ~iW[ S_ϯ_m5J8*I~gr~Agj~/N6iLbugoCGNj]oj0kz[H%$pHCfL/'_}T$=*ܯoWNM8{QT@QEQEQEW~@%ص45ߴ?/_-j_M%[_t QbUk_ GN++V~QEodeRc .Ք6 $H_Y=FH-My}3tH@ц.7v?GߵދIxVhNR4ON3kyC /?|=%;tc>3:y5Yŧ,v"vf5SNz{<{j>xVmVTZP-g5R1WvD23F{W_#} Qk??*?4'[xH|CKOS_oYmĶ@McOPX?W9H{t??{_<ګcE*_I c+) ׵4gĿWi>9kNb P] ଺c-aAfI_TˎGx?Wҵ_$G{+ۍBg#*a}6ZG'8?e/Kʝ&?RI?5h|GEĿšeMa#PHw:)A-d+ĖV%ăYh--X`_BEyu&KW]ɯRvE5?5|\i?y_5d>OWR؉ngIQ乕KcZO|gEɥє=?k; 1#?v7JyPM~8g[M~+Dw4ڕo?i^՘ilp(mB5,ᧇъ۬w.xf&$C[؄fbI9'k SƟ.WSGf\gI8 ޵_J"=7SD÷(*( B+oC× O EM_wWDz.T*i"HP“ksVbJUo;e@L?]dOeTZo 'YCT҃j~8-aD>EnVI?[V'x}gN,VݟG8س/[kswP^CYws"om,9¢$*z+ijxO[[oiਜ਼d{0??i_4xr91BP(1S~? ' NK+AdB>@0R6yU}#Կjgt$QƲZw?d-HE4P0(L_~ĞԑZXљ>Ye!\{aꨠZn4bLO.w?X~`տLs+,|;spW@~6xUH/)?N|OqAy*_:dž|GjlR+X`V[:(] :IãiG'f^7at6ɣY>f~?jNDiyئ>W-_{Mus~fæiֶv"bEU mtMAfFZx8VWVΑeZ'ČQ˔dRVf=΁h:]췷ĸgrW[ xÛy jԗOvtLD?Pji~~uKvmq y ~eXLæ\>pD ~~+.j(0?&?ిZ|`_>KOֳ{Gc8]$ +]=s xO6%k B(W㿌c ~.Ѵq's~__$%EW/u=ZfߊVg3ŰDcVEP8LWѿKIk$-{z ~Ge"0&}=%O|g+O_}T-^QZ?{n?cVo@эXﭏXWoMw.*?&?\U͉3n($h(+m|S [ZBg4Z w&3 "Ґ5QM1ҕ%cKo9[ ڶjWܭ-F>[iO/n}1_U㝦rr2S\/*5V+ r|9O>w2nQ&!<zz9oh(1qUpuUj.VgcxD?[jt)qk uB;;ٯ_|HGmHc].Xab u؃^(Ž8EzbU:Ҽad~s}qM48Te$_ R~ ^x']:T 䕒gB! }lj|RR|K]Z@M'#Lb:0"$=zW>ď_BKX>y&d\!.Ob>|"~~j"X/B2gwʠt'9V? |dmـ/z0Y}ă2= ?no xRttiҦ2K1c_U;&VDŶϕ##^_b6u; y $x*?ADBcS o[=WD! ¿j ~]O^esHNgHKYؘ~[!x/~ /b;sp!z3_~%2jrm`cY۲e2g_ZQ.[yEfAEP]4fbTdx2k*&m>olNJ%ei\7ٔvF=Te}|@q)Pӥh/MT8*'crcN-}NF !>^1gXw<(=ֵX El3iZ" Ѧo[q_A.~ m-P]ag8A쿻/W91M ˢ?ࠟ?fZ?ڮ&e_:EN(@ట[|b҉kP-lG? xSV%k_s $C+i6Џ%kL+.Oz|KC$d}~OWj-?h4 >9$F? Zm?أR]WRe28p3JE~˿N_45 ψ:8ID(}?vv.¾[VQE2B(ebΡ^^SWɲTgPwks#?>+-3W~!_i[c( B?o~$4`!ǨڹYu(d}+ƞ*W Dұ~ ~2.oqQy$Sh^4^r@QJ>M{>/N8~ݳ`a_`bG3i;7PFF ߇?_]CRWov֒#ekPpG]>֗meck$QUQ `VwK׿O3gv G}W2U|(}O~о(B1_jrv+Cƿ&?jn5"Dw'm_ԟ}F>@xʼnڿ]k+ ' &ҫjuEUU5KMLu m"i縝$Q%$/EI?[<Þ_ۏ7`pYdB*>@gm "`fd8>@W} T"*4z''tux[c痖Yrz' ?,]IB}/тWHϨ }W|"~>Nj>!u ̞IHDFU=I4c{7῀|#HgHEY2XL ůvlU|gXk;$Zh?4SS/ҝZQ@Q@p?6xg墱q[Ń52I}_Wŏ 5fqiWD#$wDMnJ?Q/onV_iXSqrGP6qd߉ߴ-LJtY;U~y1=OGSZ֯i<Y l? >֛ 7HӠ[{kX IIԥsFv>eNw9NK75gmI=_~Zx/ŝ췷ԜU'WqGBF5 X">[ uQ_KT`HР>Q?U8L (((w ] w!Z~ ]CI=DT A'޹벐̟hӮqovUfxOU/?Rip6Ҍ2:=fѬ]ד7u=ts%|DjA'_čc-  VܭyYO^0ذ2ZN te',.{EUQEQTtsN'[ tJ.o-[k) z_`?%iJ/ $/1/MITw?$ &c}~7oLP\>୾WtJ$-, od+h߅<B~pI >DLU35?zC8x&o Q{7QtBkFpGb"~|n!GZtmG5`U'[QE 9QEQEmxȫu, ?FE_f678ɽ1cLXkοg7?,iKz-hbLgş*g`?br"G+OZH(bk|=/hωZlWzft?ƿ |oogm͕G wLwzrw>+u&ѵ:WsZG8\%X_FZ^?os MVjkGoiõțYa6?: ,l}wE{ñ>(3 ( ۣM/_?Wׄ~ijI7ȝ+\m_?F%[c^-x}φWi· 2Ž=/8+7彳v,&H r]/7. s"m%̄<ē5E||Orkav m #S.1?tV{m"7Fooİxf'6(ZB|?O0WBe7~Ӽ /:ԗw:Ǜ$^Tcs}k.3|1KM~q-3ɹ|,WKHWdupVCE^҈tQEYQEQErVZ; iBq p|a{hQ~ק970$j=7ٟG5 ,ORD%YX`:YsX~|JkRi+kϿh _ZԿJ?־@xy־=k$W?WJk5x+C nx]T--C_+gOxn;V[q}(fJ-ѣvFYN#[c Ծϥh#E%}_L ?h4ѵK-iptuZ[%QEDQ@WKѺ6R !ea _W/=x-ׅ.ET" ƿ#k7v?t"$Oe"w(Sѵo>⯆WAo-bsRu_YclF=~խ(b (<_bj+)ػ{ʉc.}42}M'o+ƩlD  &NFWU/+M/U%_Io5T_Io5T[jWKB={ឲ%,dh#_{fRm:>Fl2+ 6fr*GF~"WRK;O\1o `%ƿzW\O pǭڡ?}HXf8+P4EQZx.(|M m"H2}de@?دp?kU;qy "go#In~N\g0>y|Y_I?VF׊'Xl~ azo#Sޡnk-?$-rs"O?qڴ1??p+f_*־?xř޳[:kBHT=D5KZ-uLOe{OU 沾LKcPxz1!?|n[ⷉ| NJ9c΄H= ]m.Cw'`crpгenKsw?~(#"0 (Ox~ $_3> VT>=j5FRﯞm/ړG/M=NѴ`dmzOԀM~PhOsm@0 i9R9 ~_/ ]OA6Gf&\jw.[n|V2YokN[/$ITĖX=m5):<Ğ |_XFemp!JWQTA1ĵ:?ిZ|`_>;&MZ]$ +]=hbq~0oOG)6mc-ħE7;$~A~?Qo4mN_aXRvn:ھǭ{ǏO[W ~WY%$z||/ |7/5}J*uCfZ\􏁟{U_ Od%޽HN%ېJf+??H?qj> sZiHt=J ѾxKK߇"t}6`*9$I$Mn7?Jv%ɟ="@4$1YjW6СbQ%eQM}{_,?79޿nbx@k{~)oc( O=71qRvwmm罚X\7+9 'b?#]UqN2&x~6n7q⯊4ЍuVr>_:[j\ y#{lDdϣ."77gh(0@((y=_o;dU=OU`yt5_H^(Omٳ d 'Qmt~Tw]$3ƓC"xPAՕ7lj4s(IlϺ?hߋOA23U,~L!Q_* Srhrgr!.џ`ƽׄ˼u7(HfZ 0SiLְRxnٓg[s'񥇭iA9:+gJ3iSE@z?aO!ttҡom^C_/sݚbBɞ^0? h'͹_S|>a0x񷋗h H?JooY]-̞>ڹb!fe;Xխh$WOC+?R ( y x^9/Nl,olcczɮӨ?YΖ_NM_GaEVQEQEQEs~&/]Ekh̩Gv3^GFlyϟlw˟ PonJk UUI 9$Rٗo^<i MO:Fۇu=A5g&?v~.|^Ⱦ9S] vO*]KoQ4xKCK*~:{5F//s3+(ŽpkA9O;IܤIUWO:ZWܡ 5qa Һ\F+?궑R V>uWk75;otOs2hS*?1І@kO*, {ikoO٧\&j[DZ1BpkH|{ >M߂[.mV>3P@K5~*J$^wZzNn:օ-Ky6 ma|u[t\MIh[APXƾm^1whq!,Y}+~Ϳ>)|:߀-KQuO5KZE9sgmlI`wœ{Z=}+~ߴ^S ~lsuz-:c?op~{oӖ0x?X$XTz&i|vHүt;Ǚ2} ^8֧n=CHԭQ ȯ5/⹧Hg| y)֕2D3~/Q4-;M֗zmf).YbUe`AZm\Iw~|X'O-լ##ts!ȿČ8#  ]⽅/YBlM8q_ƣjWO ݑ><vQ_)x [z/b~;q8T[?ctO%[#T-ep!2+?mS(M$BO/OyCq9MObh\aVeaA]Ϙxs~HVܞGzNn:?҃/vaXA[&LnjVQOF|wUE׋?e-#ij3>QY!oa_1~ɟ> ׼WVWm%pʈ'YI<Q'txR5{HﴽFK[iFVXJ&tg?@^ =/}KFSoӣ5žIDvPv2$*?7ρ^"4x!ݤla3Mlv\"TMx97^ e}Q5&m唟M I#ÍYOhd{n=y'3|Atخ5c~9'8~#UնfW֌:v+^V%?S}COĿ3|0ҴO Xځ6-#w+, zn~ +`è9٣υ?,uK_4DլZU\* e'!I ů8#KeByL+)qs؀r*/o|'[QIi04Vτ_N4h,EswokŦߴEgr;xRJkc=p}*/ixW^ZNl )؀{Wg}5fK_k[E>Eڪ'lꚳ'>?w/ٻM̰dͧ(E{nO"̿AN7_#L.D:aⓘb?~)ua0@#~ Þ0VYɎ$vB,9-'|'zN"Ļd~@k/FӴ|auZF$X4n,mo%_wV^-X<׌‡.= ~߳Of #]minGND?WZcinx]F뿵_z":>֐A eK.0dc dW?n6-4p0R 8N+wWW4[aZ0BgwxteI3ȤLqh_ 95;hKGNP&_%B,IGUV8#5 X%l5>Q Z[$d  g>~|B!k/! Z+SuٮSguh$[d;X˫ŒylIGZC[Xa7RzHoF?f̩ %fu]u%#* ø5_?5{V΍z'MñC @ M;?)}1|[-vcլ#l$˞7=pF@bk7ď |V𵟈)kZE'|8uVX;us%c,(?c=7 uf5򽗄hكZJ񇂮-AP=*UM)~|B5 9vi"DO:r~:b>~_oj_ 5Gs-rmzm鶬>}tE%Bq]Gd<j\ɾMFf9,˵Iy~ɟL='ᆧe⿉w6$ mtpZ!gA:4߲O]|@5[xĐZ[L!GPG`Wtbhf*.5S^RD:u2I1.}G a_2|1*i;N^Gw?ݓiFeT_?쫧~ LӼO3\iJ>9 9T{Ʊ> :Yфs.QM"~|6;Z^K39P *N}/xR@|9.wɬBY۫Fqt/ďzv𖣩c398?>95%xT __D ,cU•͞dM6ֳe>?-NHU}{MM.tEzqdS_8#;=Z /,I ͼO!Q__4^>q7Tעh>OX8y:`?8R{ Լ;}i JZM:YHƮk0 6}kiR-iu05dýh?'7_ij^c$98bo*MᝇGir^m$a=2&_3cºZy j8,H4Ӱ?j^gҖ ̑j@-2D,BWeI(Λ?jzhVnV}#u*=E~,xDү|Yv{]N,']+~6A;DIE>ࠞ >?#,e'Fkkpv>_ B9ȯu"-H]7z"{n=y'M~0hem Qu&m唟M fo%W| R;SRs,0?w=؊5i3:]Νi'RxV-ExW侼o'Ԡ $'$Ue_%։)KNK멉b- \:?_\|;g SRApjy/7HuH+h'sOrk+C ((?oZ[/6Pdl$zj8۠ ENc? j/4moOҵ[9 Wwq䉇b^3~0<\uO/4,E'kG|A?dWF- Ey7`^+988>0)>(x*{\xJAkz;>gfu|)eoIkR,#bv=6+5up A5xg_O$zA2\Ҫpv 3#x5DEPa\[XS/c)$ _?߂v7aF3o'/ Ř5PZEőǒ_]g$W|2i|n<2:,9kv+3G;*D?*օoeUg_q?oF+o%IoV.ya6Mڵ"K^MO^ ;5|5|whpqߑq_]BOv QԁX&_Az״ook5;KikSj1B miTa/WUcNwg-5&.u0޿㵥i :}k^խFNNз7BҖj {T42+l^qMkdՏ){wm&M珴ܟ8>-]Ak51[̆9!C#*A8~w~J[?]徏q)2K"رrcFy`T\eђŸQ-RiŚ cy on~}oG<(t& ubHG=n#${sI܇5O?>xA~F'aOqO,$Q,Qܓ_7|p|!+ ſx^V9$iPIa_zO?h?mcϋp 2[I)ԑ_\I+վ-1n04ٖ|`Q9؛%Q@x}^-[YM2(#3s˱g`Nx޿`>gOx[H4kPDVA=Xf=Kz_cC^=OHƱ6{^\ZI!HOaZd4t:ZR 5VF.x0}N35TzNn:lh~ ~a"ƙcE5}ANE5@Q5{p;%z|3w7 ;\}j{'s GSY2{UfՏ!,Yx9]kwFO}:5ue,z(;FLT=+/`O3RwmFS5&RV1kBG]ZO2:V LZĿ z ԓڹ|=kjg#U%3[crUY+<߆P\]<\γ8V2T{5߅01]>]3Yӥ0fSєÂ#zSk/{$mC@.c Tx&^j_W-c)c٠?y9O;JM~W|exdGypv_hIQWաS)Ƣ4M3sNFe7 z&CP.R.<]j>ko}^X3]7~ |Ckm4]ݘ.{) ि ~Y\hZ~=# lq:ט~__şG;%A+(|bu I?>;yfouv?L־?ik +pfK~/%dg_ ýh?'7_ijIJe}N\joT~Rx 5o.!t[(o5Q(H2XW_#<9mOsE2)ky2+ tVP2Udg@F }<=;I7FVHE 7ux*ԼaG^q.^Nrrʑ^,B֤Ej%Al\lsTlko(/h_Zs<t`S(/koA7HF\tT7RR3x jA ?:j1?dφ-|04<=/$kNXRxR Y:DO' 4 ˩[P}}>Y$O*.͠єd~^,մHMm[rLx~%_iO k@͕.{jv T i4B25 `6ޝs2(ie q޶+?P[W/ehDvF-,wU&QE1Q@~FJcۿ>0[Zn ƝvbHcz$qΪjUi7Q3\F9QYOqI;dr42+u )ֿZb/( ExDԔp<$c98'O5ֻ~Bd jRU>LsǢ|#;"'50FNn \J~ j5FH9Y"u6ziWX=JUG'{Ÿ~$>1kŞ(c^@Ws|-?h9!4Gn5Y.7r##JIj [-Y|k n$?fݮ4O8jY eQW$吖=I7|Iiso\# Ѥ`M>#Pg xGEli6d-'w$ORI'M\N z(!EP_X]KgFg v $@pUU\/σoσq_>1GW:xe8_vlaGBդώTuYH+5h"lpd@&ּyWCs6̐␼U zFr ~J٭x=k%7/|%5?CsB[nmP@'{J_wD- ZڝM; O Rx.#Ya# + _ AgI+xct}NZ~ciuLrApqVV;> %nxWZOkSo8nr1=esT]֛iq3$TahjN] [̒>D>3WF񍪈!կGoK9&C`1i?$Z) v֧)P xY1OP~Wš??ehm'oeg($I$$ɦ'nM;Դ=^/tFK[y>쑺e?PM~?.1M/#Lh_ &@eZ./]xc\z7̌~YmH8zr jč{tf:dl2c*daYIR;k[y|/բCk6 QUK/VEI ͅu'$7~x߇Y"z+'կI> {}{ÚpP{2Q {M7Pl)OW`~|oYꚒI$[ojG~x>,d~5XYK37*&[x?AWJnv}֝y_xORVL\YHG1ʙʑ=2 ע߳$ %\h^ 3HcrKDknьc(>W~=xKJzl%wty3+610:য়-d$k\'Mw=w0_osey}a]L@XdXz>$I_l"þ-I]+ST ?+_a|4"MA)ڕWD8Ɗ?r[/զ!WJ3irX 9p{x9 Zn?:S_cC_]OHƱ6{^I+!HI +Ox ăn%}%%5Q4=3U_wD?fU?k:m;z~_h֕`* ƿ :vq?up615ic,7.>&#&67Ki@8Y!>g_փYjV2/lK%^"0ea i?'%Peȸ7=ʃ@8*FFU8#7W+6qe_ ^r"i^eRh,~ |')O _x8_Xj[/0Y ;q?34g:-ⰷo; &:N~Z|8)㯋z<+듹{x! b~~K]'̐xXB$P7Q7# ; &?.|Qsjz֩]r5$I'⻏ٛ_;7Ɨ(Yi[ȑZ)J#,|AXanaBƷx rS<|2׼ 2iƇizlQ^9AMXExfZw4۽1$WtK3}Aw]\|G.lYcbH8 AŸ 7z.kKeSKnWZ?߇ V{׈G<'*ӹIES$(((((()0=)h((((((((((((((((nGEQEQEQEQEQEQEQEQEQEQEQEQEQE!(:(FUn(^-QEW_?PƿZ\y::^ӆY4;;ЕjƇqk Ѡmɬ 3ZFq +uLk}OʟSNmwÒ,bmeqX1\#[> &ݖ;:DwVnF@A# S@9$`n+souhຄxahQ_>W:W} x<=UCLi%}Oۊ((nv)Q@#(n-B})h ( B3KE7Oʔ: R@Q@Q@Q@Q@yO]&SŝCI޽ZebΡ@_F|WZg͊'3Cr?f5QZ)h ( B~P )Z;F~(((((#4PB(9 N)~E PJZ((((*@PAKEQE4( ( ( ( ( (=@4)3S @KEQEQEQEQEQEfLPAZ((((((((j~T@ ( ( ( ( oџ:(B~U Z((((( 4P|Tb((((B3HW((J}(t ( ( ( ( ( ( ( ( B3KE3LbT1KEQEQEҊz?:hEEQEQEQEQEQEQEQEfOʝE t((((()P uЊ:(:((w<5W> ^ii~Mʣ1 V[h]{(i["f'ڛ1XԮ&A4߻<:`u'I\,uO xVw[w2>[`zwZNω|=?v~؀&Wp'MKBP(w2yBAH9BBeQ4TE 0 *R7ˢ? &?8|/ty?m u;{Λu%ݼ6׆d(}<_p>|=d2𞛮hBF?ؙp0R$Wg?^++$WneNs ?8 `m+|H6]OC:vc6q%ʱȅk`dj[)&>=#?>+-3W+ۿf? z~|?K(_+۳ˑ1*Vիʊ??~/|p¶^z-&UNT5mVZQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEbÉk GXd?I!?;>Fzφ5Vմ23H =oچjqFqCh3ѭmTt˅݌,N=I?8.·WZT$H6l.)pڼ<[|/]_ÓLܷai'b)3>mEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE##޸~Ͽ u!_uYɞL}נQ@'5"YiUu_6?J9-| m/᷆mvf" z xආ;x#R8*tQ@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@V?Mi myߜG8Z7Ii} .<4uʖ r]i׶ĕeY#ʒ+O_;zD\LYQ`~д+ ^k!U$'_(QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEx-?0ȧzVQ11=N;@cqt^[r%Rr3*~di/|Dm-? H`B$ek'o};⧃,u9FA0~pA@κ(AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPSF+>6ė'-T0yb!i7~񾵠&qxuۉ(_2q3?-y/_ \ilQ,'J^@:/-is2WDmF ?R}/z̏ ?I\b뵤䜑)_Ig%K!La*Ns>>]jVtEoȚ\t{yZْeHk ~J{V Q3Km*$IWs\ <q:$Wa9B>Wg9gVp_[Esm4wx剃+A\ǃ>*cZ%$$yV鞕O&Ek¿Mk0wVcz?'hGۍ=Euo^_ϩ X^y_H[j''\ z׍MZ}2or3}W'UƩ㛿j&O)y<P$+á_P{aWPi#Q&xDg@'( on'tt)Yt9c`@qy'80)"/\sf."v](5قO'tTs"+yǥs^53x?H>6^)[[1c|# րEy/qGiiVポ <;+hp/EW,02--7=:Lw7T]B`3\{#?= -x//[oVG4XO6oJ4IK{hYjI=:ΟFFP~6Z1>ֶH-ɺbp<=1}:VσbKq]綵6Uzg'Gv>񞁩"4IHnrkc95?ZҼC{.tUP*>#mWCN5Ryp1:y\7?/ .9,%݌GC8n;QE&;7Q^ gY?kyKnt$kX@_Y]x FVKմckp>fW}+ GKq(S+SLo"u}E|gG"դ!#-jn9;9TWF 2NAuV0x<5(t+<廸i݌s">|AYq>?MKjT'Gk? ~P^ۋR,Z{IUY^x/^7jExGe>h NJ{_hSjV71iDz>Ƶ ~~W%A\^OYի-E wx_ϡga_[}qp23|Orσ`"eު%ܮ۳s;3ReG~4o]2eOܗt~wJ-WmtؼۻmcikFþxxXqaG#w'> +cp<]̷EO 9"?p}ҁYx:yc4FwΧkZ &"HPO|WቬXi խ/6y>ꪇ!xkſ|A|Ewr$CH9 ,`#8r c#F+YWLM{&Vn:h_BHIui /s~ ;7Ծ+Z<;j{Oš>ϴL.2qglQҊ?krywC[R'PKhh*|F&o<ճILy7m'Z&x|3KXO'AwF5)@Q@T7k y}z]dgZ/Ů۽Q-|c;zc>=Eίb_iO9"w$c czQ}2&B\u A..M|A/ğ_Ѵ+tY%h,3H>gw=S@=wz͐HS>2?\3-7^5Mk|So2ɏ7_a7 =#tpߐ ic O\Ïڃ |N:Lr3wkoh#*YxKԴnٚFTs8ڲ>5|mѾ /T ,l4:FFO@E$woJb״yAInS_hsTۘΪ~b,Vp26;OoK'7w81B Q@ϣZVͲJ?0j|[to|=-7-rT @?kSHßK4J@d6̸gcLT$7Wee9} ( ͽ.V9&Rh nOFK2^][6f񈕿 HG@sSi1m[R5yT4k*1*IO>FzuooF3s,ʱrx+Xm'Q&ãPG :j#{^^xJg/t0K@¸ݷ:H?F=pnL+=|h0ܢT" 2ZO/wӶqWΟ<)uG59/|ܮd)'u@X>4~kϮh,K|͜+|Cn:[Io(MWp"(=E|%m^ŷzyg~ۡz)MFwCg;:;dc9Wj_Ρe<,EmbeVݷw}޾:>>D/]j/*񘼽?9Ҁ?B7Q@ 5Oo5=HG&`(lzMSX-Ύ)U~Q,D^9 P>$NO*_X]ơ(s=et9OD3A(뻇pk'D&qz|pġ~2q־XHymZgn 4[#־5 ?|kk˶ӭ^@mv3zGϤIٚ}&K }E/>=p3ڀ>=E>~|}V,4r>?1ްgσWf#ķZ9Ӗc3o߿6~Aikω>""7vS I#Fp33F}S`yqd~-kÞ*>00wfacz(?h|yq|vtgn 8"^+QOxjY|طn7x^#H#&[T$,jGO5> 6cԸ4Xt B9RdWцC)"_ ğ}\x}\y@D$&\ _)azI∐[>]ʎ{yFFpԛ+ό< ?]޽[ E\n1ӵ>=E+Kg럌^6mMvKQk%Ǟ~R?^d"}~,m0y-"A``:P;o_~Ο'l|3; KX-)!D2yHm ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( +MW @:K}_*Ka}zW2:zxQ{*6zb;\֊sz\Z&N!2iء mx9 >!?R@MmT[y(?!U] RQEQEQEQEQEQEQEQEQER^)k⇃/ K6"pL :Õ tWDQ4: kPrLؐ0OJI)((((((((((((((((((+/v[C6RSWv=_uaC[ h8?o!٦k` p3%>=+Vqi6Jk޾#?_ oržE/N?€gu$ m#DPY~~x{4w#ЪCO')tYvjk8~eoȅJ?dAq }{+0PF=wzK^?):<c.O{覯yB䯌c.7pM_fПE55=Bx^3lb Ӛ qxKz8 z߈[BK6@AQP|QkWqskk$)Ш|ҿ64S_ Pm5uV"co)A~V/мb隬Go;t}~><'xcK$[m>-b }_,tHs$Ұ5cƟm3L%meEA*O!e\qڀ6?a~$aȺKwc>7_sל|-KF鄗̻L e\r{ף#&?j?M׿?k#h8nN )uUCaO0bkֿ[Gm `_!ʼnhz7/ GV_wgdXglRk?؞ *QUQ^@0 u"HK Ofr%>koh}Ÿ~8"8'~PAR2_/K/kPF+ّ@ 8I.7sim]ٺyKh:(t+Hga¿T~WT08P4~3@)h^){-2[4 $S)rD{gSRxbš5ގ%-lN6FQڬ~\w_ ҿ+z+G # Wz_l!F!n.!p:?  mK#M̚zS" qᯤ/ \7o FbRJ/#Hx='ђ1i`P\f/}GY<=rrwFR~PIo|"=+ӻ+abx7bX̄ǟ'@sQE(<9Y-mo/B6|>>o[&%66Ôp\?hԾ7xY [քn@~+>}ñɸP>E C~#Aw<7X=N#l?Q^EW~WO}gI gRx'3$_)@e_hJW=~l~_^6i|,+[/׹F=9?n_#?EK@# #WlBW[|L-%hu=e͜R!G3#||]$~ -JoO^ȖᲒ`;e@S>㯊D&Ѣ7Ύ2 FWe|i2=}w@01HDs:s1IK:2=~P!>^8k*yha%#$Xԟ"Ba_,~RFovnJK:?t1 Ʋ7х}I4o #3Rkٲ'.TNmlK\{H@?оW{QCie#c/W OBЩ{e3貯 5xo?_i~)<ϥ{XF 8kkx>O"5 E'NP>aF>(QE??Wm` o{$+U+O&:|Iu=GbN@hC;KygEv=&|;)-OKePQ"%rpp?u_ڏ5ޙw !X]C  ڷ?`'!JtQE 9kah\-|q?.Z7=Оͯ`_x'hr|h:j: eE ~hZksnelnF*}T;_Tq_-JKmkS[EhH2zw տj/U弿 !X]C O[wP褠,}2t+G u?~7G>n9[09S#Uk@Ӹ_ _Q<ѯ@O;x53g~ew-tPxwfk7YF%hrAkO u ZfMRüx_ko~ >3Bz2zǟ\|:O{PԯTWF2NAO'_?CKR>o}Ϗ! Ħ_6?Z1gl֊c5{6ڗqB1Ü7 zW?:Oêhi#mhfmW^Cڧ⇃|9OqmgtcgԨlpTvO_6ƾjpØCٔ Zw.mOl/d!"գ!  }_<%kO iOka]I L"ujȬȋ/\趠GW%~e[!_~P6eE[% ~jOZ@73h W,2]}Jw*GZzK|_AzكᎪ3?$RP),NCЃWnj3k"fejP?OFbmľF 'AW??r_$?6DsPWqXZMs;GsT Wo[duɲ?qO$_5 e]Xt *+ aEP#;x3o%Bnu?)͏*V@Q~*xvSEIhE0mߺzղkZ)ֱj]9dzp<`? |TÚa1)AsW=ŵF%Q 7:W<+_xSM,{[19dp>&h8BEF6C#v/-}J##@'&E|5$_޿Z&E|5$_޿Z?G(|np/\"O ,WCnp/\"O ,P>UW [}k_%~߿guQP?AZ?u6lem𯎿fß?z审#] 4u`\=f>;~67߇<)cukmzUUsȊ 'F9xoۍ?׃$Ml "$~5_-_6~4G&[!27R ]8gg%_BmRg%^w2սQG8P&94 3Ǟ0u=)&gUsnTqqV߅|%x'GJ,Ofu2H'|?^ ׈<5/-RE2)S>q??DO\O5vjn$zO߳_M/ R/΢,BoPwn#}m_/߳e\m1|Ѫ@o]t5zĿ_3't;]Lu2%q 3U8;$ߥ{1E[PR!L6GʹYH-(KO'/_SF(__rUK4o@ %2O $1귌,uI_.ߋui ^+*}Av@}f/YvfP'"~) yE=IEL0jZ(E]SLִ۫ R&h\e]`f|Z/o{ߖHZ㮨3[[% t|7 xv%H>W_¸ڟH'?>:ao>\C!bGJF~.kxb?,`$Dmo()ڿ5gϊ6xis{nm$Zݹy cT_j|3m6= -@%DT3H8$(|b2Ŧfk>L{xCP9_,~߲kxoU_nmaV6%8b:_UP (QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEo;Z7̏,=O{?N/`_~/|Tlۨ5PkB=vڿ7ZeBmm2Ƞ# E|EG|/w~wTF)uJ#g q{&Gw칣>;hwShq!:FEy|J+:T˝'d{zر޻>%񆳪xTw_J2iM֡&3<Ö;JB$ak7SCWͷO_`RCH/ˬYwBH ϥ+^y߅ZͦxpV d$Yq}LZ>$x /GmwVloLW xvA %}Aˏ?WeE|qxRM7UuneWؿ}+ˍBKWVYsrĒ~\Vdzќ_m?~$|MbG`uI / L`Iq?I3Kkzq#]JKE d\-Ϲ) @ƙ?_o!I8ib8YW=/JNQ޵=6KKec`vPs;K`\ZwMcαOX[iϓ}b`J*@t{vuQ?/.K(5k[mÆW Np_z.;isz]W5]ŷݖy }^cc }Cg?zDU~!495KKv<&' @HzsK_?ߵ>x_:kf-J,\zMNՏ/*?Glq~iGY`o-R/ҒݍQEDQ@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@|OG[ k@kGЖkφ1R~h~ ^ |N[3bm~?u*>_;k#IxUсVVƿ3>9|=7-KL.T|9LU }VGgS_{2CuWП??׃Jd/fp,x~ w{5~?IÑ(oK^?):ta2?_~&_P˿W^%_P>T]}O-Kȧ@5Ajo$?_:S}zj$ͼxH;H`:rW$hyo (u[x D.A鞙@#$M4rO"GO95ඣ[ cŨ[VmCvk2ᜑ9?/t Q@o~_R_)t #JG RC G\_~2xCὌZͼs %lq%ćc?"3xkAbP@_#~%y?CuO7S}2Fg\'ĿkGĤim;M1 }NK3t_oc9d]f~0#STqI=@5_ xYA7~~~͞>׼!kMrxiuu7C0Vrg#${7z'퇬}c4?ҵ[R\ddOt}HlGkg[ăQT(.?ewpIE(wrF Vj+y:_$鐲C)u= ~߷gx1f䎞b|OR@&}kV$VK&VPօ|xx Ļ9('dxW4(3/7knDKX@o}\~Q☵J>Ѥ]G#1[K8>ů Gu"CxhC'q2M|?⾡#Kyk?e?elzt93SEbxKƚ'= QQ}?e؀khIB^SoC~,4+;׵˻EXK0\ c?td~o_U_wE蔯?jӟ**T~ D{~l~_^4YW~ d>!]WQ%QkxXAl@ǟzoR)/}4?Es~_|'.|fK+h$꧀Gq'!?@+  mkcNd6LW#?iOşIִW.mYR`׮~1s̶XId'?=}A?_跫=L$L}F>~G脯oo _†[N>8t}oI gK ^;"O`2QЁSK1i9t9\!X7= QҼQ D @=^8kOxN-u uX gk #?%󆁣kDC_HW߰FN ڐЌ|1 S6ǂaJ5[FխV6[ư @+O~reV`%c/YweԌc #~^բ`wc 8bpWG_?5? =X/f8-x;Hdet9>/ZG+&`%E'kIku{Nޛ6^B7I=āG*w:_-n.F6}!2\oQ  d4V'/5iScmp0Pg_yQ~85GlΤryIQ@?ox_%#^Q׹ O60W~N?Tlt l}YmlFdZU|&kA(ly?Pk7Q_?mo|m}'QN=^AF`k22pE>o~U% y+بwF> 0 oς&w %B~c|:JR r*WR0A" oZ'}3}'Oo鋿-JOGii$rM|? =@r}C.f{dYs;%=I=a~75nG.[-iPE[_7ÿڷOO;MFns8`\S푞2@#ꏈ? 5?K6^ cB}Q#2ை5沼+8Q@#}@&T47Y#p]NAP<[IhTV[{")CFQqn?ݠhO4C_W/rΊɓ^|E`߱.#v[)k8XUST QA|Euj~u~[!_~W_q 4 (kVI_3~}A}3j܏@57@м_/P/@T\Eyo,ēA*xPF W7½a'ג|6rfOy?yQt+hz^mf)d2ױ5~?o$x3_66i7('{rb~"H9;|>Iѧӵ8e c׎{Gp=|m$]-Y$4 0.}e,IHSW/h/HaXk}ӵkx~էӮIS!uwvO H0# ^?h3Q헃I{d + CMǀ@NkA!kCO h 2ʾ?i827Y~}x~ >-&Osy%8h/WrXZ~B82*+ |/GkM f< w(okza][i km;  .,xMDW 6 GC_mY5iYqNg v=3HF)RxHdee9~l{}WPf75沼+8Q@#}@B>:Ukg^sxxLG<9.&DS0wסǾ yo#hծ_PceUOP7 =͋j_ ]j^ItEKyM7|wǯ K#VX}^ͅ~#d`T2 ~|Yd^gve$>{>2__4."K_N*:P#7??(/ 6E-~v~ќo~Wxo o S|ug~ ңm;G).`us߁^X~8'J"x_N:ךʿ_.__ )-QG@:ށ$I_"zGInfp^*kv+lYO ?1& 0 ~p_ ߉+gHs{bPaP?nЭ~^W8|S__ l&XQğ%P#N_ I|#"^P6=hЫ,?ѹ(>|#.]^6웦]0q܈?U忰ψ"Ӿ'ZdGOaO,|M6c{ C*t8#=b~vx&'Y"[[ius=/~Q\y$wdq@;z0rw@ͯڏ㏉eo"Z)^y _b| խW(2Qc #$u2GɿO?G2rn_91={hL)}9}A0?4T?\xTHE(*a |p_غP][slds9~;:@t¦H^Q$g# |f|2 +A>|w>4bYra$>pd@~9AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP_YaG8zzK7s'Q}? {s~;yGۋ> M/Q6fY$<^W oiw!=:4 :2"CmE{_'^]Z(l tWhbG"@5OZxoF*ݴ8I3'袪A>_s[ ݮt,mjV1( qaT ![j=3 Gg?}_\|9k~κ.MסIdJؐ+Igh/unlh *S{w>~xſۻi. ;w !DQWƟI?r"h*!9WW-KUxU&+;ڿ>?lIwks:*?,?cOI/׿SYbZ yuS]{42H~HWO6}{o&k?Ӿ%?&^;/1x?)~5韰lv%u-. R%S=̀e~m' S isK>,ռ(4n"%[$EgNۂ:~JAu`5MVJ:Νki>%w$Ov֮|,}_i_T:+->([=(((((((((((((((((((65 CK*<1lzך/Je_],} _MWo̺ڮ~S Ң'F~Rҧ7a$F s2x.5Qc@p؅5Jqvs3bBbqt_E?\+3anMD|yf=קQ@/kkZg/"cqK`ѕ ! ^WvmoAmC{t9W,_xVƷp-Է&ZnT }5E>Qv㫸9X?e}9iz_n~kMq֕WS~k³躲m'緺@ vuDwWcEyq|ѵ->-Yayp'2<-P㞕|Go,jkn'ڣM6@LuBo69AD6pD^9,@Dw9߇zV>]'$䌜uuxPMWķ/a#ҳdm<Aξ/.|B&ßorb>ּOMI_ 2l] c!ϩǨ5E``t_u}mewf5 -wO' 5Vl#"WTP;=Gz57klC { P#矉?@]SZxuL(\g鞝O6 4V <?%}gE0OiΛe܋ e+( WkW\O]%m_GZ_*#+c9S^G7op̌{}aE>RB㫴Qղѕ=m!v-n=1߲v՟EH|vQ8' 3F=+xv Ci_:WѴP>=J1$;|?GO/J]70%4_5hUcޥwg=kb|߰l/(stlFGW%w VғVdOm[Z쨠eU|Ij:]mq_MQ@(AAlًQeȕM,v)7MEQEgY-qٵ@R!&8 B+("ǎCY/_tOI 'zʸ3W̸ֽf|'k3Ʒ5$JZ/nO[M6thw!7.1&˿nVkIȕMaEE uy!Iׇ.ń`{]}+(goǢ|cmAx&溆 @8 ͞s=~ѴEܮg N3袀94+!"sJ~Ya'8{{s^D>-+nD.! }kE|k.Q1m{^+2pR+?.ަ4)շ5 yA|t>*|>< {> 1GVvzo2 y87؃_W@aRx5'8Kj/H> f[*Ib˟)ۻzD>Pl+1xJz?_IxCIо`X>Ɏd(.s3_)OrARcq+( pg]ӵgr; $O袀 vAlf>RJ㫷Sֲє`{v-cb0JX+ (ϕ?ᅿ}?Zammcszm7k`o>3_M@\(fxEzoKkɏzs_2Mpe܋A2>O ܓ.'3)7cf3k(ϟ|'xA'ԥVϗs /'$WzUa i +;{x"@VAEPO&[ !,z~doWח~Ⱦ?aĹ2HHF">/ؿ%o|@ԑ?7rg?? & .5$qn=](* oYlllf>RJ㫷Sֲє`{v-cc)`ԯ(w>Tmh_*þ,u鷐ݬRYpsg}5Es-~_isJt:84Vv3Ҹ` b2z?|&y VғU$*lfűƊ(Oi.4Z/4r=G 5jզ6ճڭ )X#f:ko<_/WiGKiP#i`sҾ>`Y#k/ |SOܷ=Vc=IZ~?o)P,dIpk(*ETi u_;s7Rq+(`x0y!,@ڕ1_4 M} u.LFN?:ݢ .mGK}Q<{!n ˎPɯZƷǫ5$JaEUxϧDw>SoQ]J/J _^<^S*-jKEq#E#]8zj(߰|W _Ƞbє`-x,b%}aE|++?i}SCc>dݎo}?W-ۻmgR1#&FqF;ҽ| |]G,@DA4ӿ'RdVͤMG,5fU]ƽ>(|;_.hw42)ʸǷpH_=C[۱hosFWP=7J~`K'$䌜u((((((((((((((((((((((((((((((G^ ]'^{ bwKj:u>"3Em_5qju 0Iۿnf;W?A_wQJ|s[蚦>,дx\!E'l%XpyQ_IE1|;еxgRY-X5![q}1E.>:l|+#j^-yʵ>~~)_xob^9-8#Kz|qxgŷ դ5kTx0,w=_$x _B|qqԵi O¯@Y#_rE<=ԦKp\Ɖޙ `I, dWb>8$E~+1ʱ3G4#YYZ)Uh8$Oً>Y+'Ŷ4:yvK=9YvE'22CF:=; ◂ x_h IP{2_x; OogK =q|gtR0nڧWtQ`NW4^5ďj枻 \qO]W>RoF[[M`Y\ 6'O;.<-K_&ghQ J9 -:vboڤ3s_߀R? %E}{118$$FЏ?C3Լ \ @mg_*gwVa޾2o' cV%k&GS*)ؔ>(?~÷䬂&;s3gyH$ ~[ҵOFmYa7\gv WQ`>/i9jZ֯"ku. 4J\@ȯoWXy->N7g{X.QE1Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@^6Fڇc9H5 6T{3(⾓(x7UӚ_n.7{q ¤H Ű(6h)QEQE( `/ 0DArialNew HLM(0(B 0 "DTimes New Roman(0(B 0 @ . @n?" dd@  @@`` X$    ,R$d_}Ω e 0AA0 f@wG}L ʚ;e8ʚ;g4OdOd@B 0~ppp@ <4ddddlpC 0 LM <4BdBdlhG 080___PPT10 qq   ` 33` Sf3f` 33g` f` www3PP` ZXdbmo` \ғ3y`Ӣ` 3f3ff` 3f3FKf` hk]wwwfܹ` ff>>\`Y{ff` R>&- {p_/̴>?" dd@,|?" dd@   " @ ` n?" dd@   @@``PR    @ ` ` p>> (    6TA  `}  \(Clique para editar o estilo do ttulo ) )2  0CM  ` M nClique para editar os estilos de texto do modelo global Segundo nvel Terceiro nvel Quarto nvel Quinto nvel8   o  0dKM ^ ` M >*  0N ^  M @*  0V ^ ` M @*6  S f ? 3380___PPT10.: DModelo de apresentao predefinido P(    3 rOMxaxa1))?}  6$ PATHOGENOMICS PORTUGAL Partner 9 $0 0$f(f f(f f(f f(f$fhh88p  HAp9p?LogoMCESH  0޽h ? 3380___PPT10.:ХG LD (    0My JInstituto Gulbenkian Cincia Platform from Affimetrix This Unit provides services in DNA Sequencing and Genotyping, as well as in Affymetrix DNA Chip Analysis. The latest Affimetrix Gene Chip Hybridisation and Scanning Station is available. ICG also have a bioinformatics unit. Responsibility: Dr. Joerg Becker. National Institute of Health Dr. Ricardo Jorge The NIH is equipped with a core facility, providing services of High-throuphput DNA Sequencing, Genotyping, Molecular Biology, and DNA expression Responsibility: Dr. Maria de Ftima G.C. Bacharel Proteomics: Core facility is also equipped with a Biacore system for studying biomolecular interactions in real time by Label-free surface plasmon resonance (SPR) based technology. Responsibility: Dr. Deborah Penque. 8kS&T3%6 /b        N   !   a      Y 4     1  "      <H2 Bi) &Examples of available Infrastructures ('&& H  0޽h ? 3380___PPT10.:@} p}(  _  002 M Diagnostic - Screening techniques and bioinfoirmatics: Development of an hybrid neural network search engine to provide a database of medically important microorganisms. - Metagenomic technologies to examine the DNA of nonculturable bacteria and microbial consortia without any sub-culturing, thereby allowing to understand the interplay of genes and functions in an ecosystem, regardless of the specific microbial hosts. How the genes of all members of a community relate to the functions carried out by that particular community? N8u-m6t&  g     $   -   <DMIi rFields of Research( H  0޽h ? 3380___PPT10.: 5A *"(    <d}4Ii rFields of Research(   6@4  6Diagnostic - Screening techniques and bioinfoirmatics: - Methods of detecting and identifying novel microbial products are likely to be scrutinized and improved upon, expanding the ability to exploit the metabolic versatility of microbes in providing powerful antibiotics, therapeutics, and other materials. Development of rapid diagnostic methods to identify resistant bacteria with application on international surveillance systems.67-8&&   H  0޽h ? 3380___PPT10.: {{ (  k  <  AMicrobes: Yeasts: Analysis and identification of gene regulatory networks Helicobacter pylori: Identification of the gluconeogenic pathway enzymes used for anabolic biosynthesis in H. pylori. Neisseria meningitidis: Antibiotic resistant markers, adhesion markers and markers as potential vaccines against meningococci.B 8V g   7     =  Y      <ˢIi rFields of Research( H  0޽h ? 3380___PPT10.: ) NF (     <2 D, THost-microbe interaction: Cell-cell communication: Klebsiella pneumoniae Nosocomial infection: Klebsiella pneumoniae: identification of extended-spectrum beta-lactamases by genomic approach Pseudomonas aeruginosa: identification of mettalo-beta-lactamases by genomic approach JAt4             '   <ϢIi rFields of Research( H  0޽h ? 3380___PPT10.: ) ME$(  $ $ B4P  MHost-microbe interaction: Antimicrobial resistance mechanisms (also Public health needs): Neisseria meningitidis Mycobacterium tuberculosis f ?44Z    $ <2 Ii rFields of Research( H $ 0޽h ? 3380___PPT10.:LO^r(y$Q*7/e3 )O( `/ 0DArialNew 00Oh+'0T `h  Diapositivo 1omcanicaptj-bio27-Microsoft PowerPointP@ eZ@):@P닶<PGS;  )'  A  """)))UUUMMMBBB999|PP3f333f3333f3ffffff3f̙3ff333f333333333f33333333f33f3ff3f3f3f3333f33̙33333f333333f3333f3ffffff3f33ff3f3f3f3fff3ffffffffff3ffff̙fff3fffff3fff333f3f3ff3ff33f̙̙3̙ff̙̙̙3f̙3f333f3333f3ffffff3f̙3f3f3f333f3333f3ffffff3f̙3f3ffffffffff!___wwwff4'A x@(xKʦ """)))UUUMMMBBB999|PP3f3333f333ff3fffff3f3f̙f3333f3333333333f3333333f3f33ff3f3f3f3333f3333333f3̙33333f333ff3ffffff3f33f3ff3f3f3ffff3fffffffff3fffffff3f̙ffff3ff333f3ff33fff33f3ff̙3f3f3333f333ff3fffff̙̙3̙f̙̙̙3f̙3f3f3333f333ff3fffff3f3f̙3ffffffffff!___www______________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________޼________________________________________________________________________________________________________________________________________________________________________________________________________________________ü____________________________________q⼘mnmm____________________________________‘⑻ss____________________________________lnmmsm________________________________________________________________________qq____________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________@ . @n?" dd@  @@`` `(     ,R$d_}Ω e 0AA0 f@wG}L ʚ;e8ʚ;g4SdSd B 0ppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %  rEeDfJ O( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` `(     ,R$d_}Ω e 0AA0 f@wG}L ʚ;e8ʚ;g4SdSd B 0ppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %  rJevJO ( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` p0 $    ,R$d_}Ω e 0AA0 f@wG}L ʚ;(9ʚ;g4SdSd B 0ppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %     d    B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` `(     ,R$d_}Ω e 0AA0 f@wG}L ʚ;e8ʚ;g4SdSd B 0ppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %      ( (  (\ ( 0s T  Functional genomics in malaria  an unbias RNAi screen to determine the required host cell molecules and pathways for Plasmodium sporozoite fully development inside hepatocytes - Instituto de Medicina Molecular DBYeast: Infrastructures and algorithms for analysis and identification of gene regulatory networks - Instituto de Engenharia de Sistemas e Computadores, Investigao e Desenvolvimento em Lisboa Identification of Glycosylation-associated genes induced by Helicobacter pylori in gastric cells: a glycomic approach - Instituto de Patologia e Imunologia Molecular Insights into the complex regulatory networks acting in yeast cells challenged with drugs/chemical stresses: genome-wide expression approaches supported by bioinformatics - Instituto Superior Tcnico#f`x1v 1%db<'3&    R           ] `   E    1    ( <M ") #Projects in Pathogenomics > 2004 ,$#0      H ( 0޽h  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~ ? 33___PPT10i. <`qp+D=' = @B +rp3 8eL3D O( `/ 0DArialNew 00B 0"DTimes New Roman0B 0ie 4Folie 5Folie 6Folie 7Folie 8Folie 9 Folie 10 Folie 11 Folie 12 Verwendete SchriftartenEntwurfsvorlage Folientitel eCurrent UserSummaryInformation(TPowerPoint Document(|DocumentSummaryInformation8Root EntrydO)YE{Pictures eCurrent User/SummaryInformation(T   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz| }~ ,d (  ,  , 6bMT L Host-Parasite Interactions during the Hepatic Stages of Malaria Infections - Instituto Gulbenkian de Ciencia Isolation of molecules involved in high-affinity iron uptake systems of Leishmania infantum Instituto de Biologia Molecular e Celular  IBMC The glyoxalase pathway in Leishmania: Potential therapeutical applications - Universidade de Lisboa - Fundao da Faculdade de Cincias The effect of chloroquine on the modulation of mosquito response to Plasmodium infection - Universidade Nova de Lisboa - Instituto de Higiene e Medicina Tropical  IHMT Structural characterization of MrkD protein from Klebsiella pneumoniae : implications in the epithelial adhesion properties of the microorganism. - Universidade Nova de Lisboa - Instituto de Tecnologia Qumica e Biolgica  ITQB M#^4M@[QXM#J4 '=D  P3LTM   J      4            @   @ Q!        L W , Bb &Projects in Pathogenomics before 2004''2      H , 0޽h ? 3380___PPT10.<4   004 (  0 0 B@\ &Projects in Pathogenomics before 2004''2        0 6hVbMT-! f Screening for new Candida albicans virulence factors associated with morphogenesis using proteomics methodologies. - Universidade de Aveiro Host-Parasite Interactions during the Hepatic Stages of Malaria Infections - Instituto Gulbenkian de Ciencia Isolation of molecules involved in high-affinity iron uptake systems of Leishmania infantum Instituto de Biologia Molecular e Celular  IBMC The glyoxalase pathway in Leishmania: Potential therapeutical applications - Universidade de Lisboa - Fundao da Faculdade de Cincias The effect of chloroquine on the modulation of mosquito response to Plasmodium infection - Universidade Nova de Lisboa - Instituto de Higiene e Medicina Tropical  IHMT Structural characterization of MrkD protein from Klebsiella pneumoniae : implications in the epithelial adhesion properties of the microorganism. - Universidade Nova de Lisboa - Instituto de Tecnologia Qumica e Biolgica  ITQB uM#^2M@[QXQM#J2 '=D  P3LT*  Q  M   J      2            @   @ Q!        L WH 0 0޽h ? 3380___PPT10.<Str%P U0bePlp ( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` p0 $    ,R$d_}Ω e 0AA0 f@wG}L ʚ;(9ʚ;g4SdSd B 0ppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %      `X,(  , , 6bMT B Host-Parasite Interactions during the Hepatic Stages of Malaria Infections - Instituto Gulbenkian de Ciencia The effect of chloroquine on the modulation of mosquito response to Plasmodium infection - Universidade Nova de Lisboa - Instituto de Higiene e Medicina Tropical  IHMT Structural characterization of MrkD protein from Klebsiella pneumoniae : implications in the epithelial adhesion properties of the microorganism. - Universidade Nova de Lisboa - Instituto de Tecnologia Qumica e Biolgica  ITQB M%[QXM"F  P3LTM      @ Q!        L W , Bb &Projects in Pathogenomics before 2004''2      H , 0޽h ? 3380___PPT10.<rp KvepC ( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 0(<'    ,R$d_}Ω e 0AA0 f@wG}L ʚ;(9ʚ;g4SdSd B 0ppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4       P4|(  4 4 BP# &Projects in Pathogenomics before 2004''2      4 4 6h MT f Screening for new Candida albicans virulence factors associated with morphogenesis using proteomics methodologies. - Universidade de Aveiro Isolation of molecules involved in high-affinity iron uptake systems of Leishmania infantum Instituto de Biologia Molecular e Celular  IBMC The glyoxalase pathway in Leishmania: Potential therapeutical applications - Universidade de Lisboa - Fundao da Faculdade de Cincias u^4M@QJ4 '= B  Q  J      4            @ H 4 0޽h ? 33___PPT10i.<St+D=' = @B + ((  (Z ( 0s T   Functional genomics in malaria  an unbias RNAi screen to determine the required host cell molecules and pathways for Plasmodium sporozoite fully development inside hepatocytes - Instituto de Medicina Molecular ^#v 1#&    R          ( <M ") #Projects in Pathogenomics > 2004 ,$#0      H ( 0޽h ? 33___PPT10i. <`qp+D=' = @B +  p<(  <L < 0p,\} 8 DBYeast: Infrastructures and algorithms for analysis and identification of gene regulatory networks - Instituto de Engenharia de Sistemas e Computadores, Investigao e Desenvolvimento em Lisboa Identification of Glycosylation-associated genes induced by Helicobacter pylori in gastric cells: a glycomic approach - Instituto de Patologia e Imunologia Molecular Insights into the complex regulatory networks acting in yeast cells challenged with drugs/chemical stresses: genome-wide expression approaches supported by bioinformatics - Instituto Superior Tcnicof`x1f`>'1  ] `   E    1    < <") #Projects in Pathogenomics > 2004 ,$#0      H < 0޽h ? 33___PPT10i. <`qp+D=' = @B +r / R9 e[5( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 0(<'    ,R$d_}Ω e 0AA0 f@wG}L ʚ;(9ʚ;g4SdSd B 0ppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4       p(  _  02M Diagnostic - Screening techniques and bioinfoirmatics: Development of an hybrid neural network search engine to provide a database of medically important microorganisms. - Metagenomic technologies to examine the DNA of nonculturable bacteria and microbial consortia without any sub-culturing, thereby allowing to understand the interplay of genes and functions in an ecosystem, regardless of the specific microbial hosts. How the genes of all members of a community relate to the functions carried out by that particular community? N8u-m6t&  g     $   -   <S ~Research Fields for the future( H  0޽h ? 33___PPT10i.: 5A+D=' = @B +r}PeY:( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 0(<'    ,R$d_}Ω e 0AA0 f@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4       p(  _  02M Diagnostic - Screening techniques and bioinfoirmatics: Development of an hybrid neural network search engine to provide a database of medically important microorganisms. - Metagenomic technologies to examine the DNA of nonculturable bacteria and microbial consortia without any sub-culturing, thereby allowing to understand the interplay of genes and functions in an ecosystem, regardless of the specific microbial hosts. How the genes of all members of a community relate to the functions carried out by that particular community? N8u-m6t&  g     $   -   <S Research Fields for the future* H  0޽h ? 33___PPT10i.: 5A+D=' = @B +! 80(    6e  6Diagnostic - Screening techniques and bioinfoirmatics: - Methods of detecting and identifying novel microbial products are likely to be scrutinized and improved upon, expanding the ability to exploit the metabolic versatility of microbes in providing powerful antibiotics, therapeutics, and other materials. Development of rapid diagnostic methods to identify resistant bacteria with application on international surveillance systems.67-8&&     <x Research Fields for the future* H  0޽h ? 33___PPT10i.: {{+D=' = @B + (  k  <pp AMicrobes: Yeasts: Analysis and identification of gene regulatory networks Helicobacter pylori: Identification of the gluconeogenic pathway enzymes used for anabolic biosynthesis in H. pylori. Neisseria meningitidis: Antibiotic resistant markers, adhesion markers and markers as potential vaccines against meningococci.B 8V g   7     =  Y      <Xb Research Fields for the future* H  0޽h ? 33___PPT10i.: )+D=' = @B +E \T (     <D, THost-microbe interaction: Cell-cell communication: Klebsiella pneumoniae Nosocomial infection: Klebsiella pneumoniae: identification of extended-spectrum beta-lactamases by genomic approach Pseudomonas aeruginosa: identification of mettalo-beta-lactamases by genomic approach JAt4                <$9 Research Fields for the future* H  0޽h ? 33___PPT10i.: )+D=' = @B +E \T$(  $ $ B  NHost-microbe interaction: Antimicrobial resistance mechanisms (also Public health needs): Neisseria meningitidis Mycobacterium tuberculosis f @44[    $ < Research Fields for the future* H $ 0޽h ? 33___PPT10i.:LO^+D=' = @B +r vPI5^VeR( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4       P4d(  4 4 BP# &Projects in Pathogenomics before 2004''2       4 6h MT b Screening for new Candida albicans virulence factors associated with morphogenesis using proteomics methodologies. - Universidade de Aveiro Isolation of molecules involved in high-affinity iron uptake systems of Leishmania infantum Instituto de Biologia Molecular e Celular  IBMC The glyoxalase pathway in Leishmania: Potential therapeutical applications - Universidade de Lisboa - Fundao da Faculdade de Cincias u^4MDQH4 '=(  Q  J      4            CH 4 0޽h ? 33___PPT10i.<St+D=' = @B +e  |t, (  , , 6bMT ^ Host-Parasite Interactions during the Hepatic Stages of Malaria Infections - Instituto Gulbenkian de Ciencia The effect of chloroquine on the modulation of mosquito response to Plasmodium infection - Universidade Nova de Lisboa - Instituto de Higiene e Medicina Tropical  IHMT Structural characterization of MrkD protein from Klebsiella pneumoniae : implications in the epithelial adhesion properties of the microorganism. - Universidade Nova de Lisboa - Instituto de Tecnologia Qumica e Biolgica  ITQB  M%[QXK"D  P3LTM      @ Q!        L W , Bb &Projects in Pathogenomics before 2004''2      H , 0޽h ? 33___PPT10i.<+D=' = @B + ((  (Z ( 0s T   Functional genomics in malaria  an unbias RNAi screen to determine the required host cell molecules and pathways for Plasmodium sporozoite fully development inside hepatocytes - Instituto de Medicina Molecular ^#v 1#&    R          ( <M ") #Projects in Pathogenomics > 2004 ,$#0      H ( 0޽h ? 33___PPT10i. <`qp+D=' = @B +  p(  v  02M Diagnostic - Screening techniques and bioinfoirmatics: Development of a hybrid neural network search engine to provide a database of medically important microorganisms - Metagenomic technologies to examine the DNA of nonculturable bacteria and microbial consortia without any sub-culturing, thereby allowing to understand the interplay of genes and functions in an ecosystem, regardless of the specific microbial hosts. How the genes of all members of a community relate to the functions carried out by that particular community? N8r-m6&    K     $   -   <S Research Fields for the future* H  0޽h ? 33___PPT10i.: 5A+D=' = @B +r$<S I eV( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4       4,p(    02M 8Diagnostic - Screening techniques and bioinfoirmatics: Development of a hybrid neural network search engine to provide a database of medically important microorganisms Metagenomic technologies to examine the DNA of nonculturable bacteria and microbial consortia without any sub-culturing, thereby allowing to understand the interplay of genes and functions in an ecosystem, regardless of the specific microbial hosts. How the genes of all members of a community relate to the functions carried out by that particular community? r8r--c- 6&  f     $      l   <S Research Fields for the future* H  0޽h ? 33___PPT10i.: 5A+D=' = @B +re( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4       p(  k  02M Diagnostic - Screening techniques and bioinfoirmatics: Development of a hybrid neural network search engine to provide a database of medically important microorganisms Metagenomic technologies to examine the DNA of nonculturable bacteria and microbial consortia without any sub-culturing, thereby allowing to understand the interplay of genes and functions in an ecosystem, regardless of the specific microbial hosts. How the genes of all members of a community relate to the functions carried out by that particular community? \8q!c- 6t&  g     $   -   <S Research Fields for the future* H  0޽h ? 33___PPT10i.: 5A+D=' = @B +re( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4        7/(    6e*, 5Diagnostic - Screening techniques and bioinfoirmatics: Methods of detecting and identifying novel microbial products are likely to be scrutinized and improved upon, expanding the ability to exploit the metabolic versatility of microbes in providing powerful antibiotics, therapeutics, and other materials. Development of rapid diagnostic methods to identify resistant bacteria with application on international surveillance systems.488&&     <xW6 Research Fields for the future* H  0޽h ? 33___PPT10i.: {{+D=' = @B +r e( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4       P4L(  4 4 BP# &Projects in Pathogenomics before 2004''2       4 6h MT f Screening for new Candida albicans virulence factors associated with morphogenesis using proteomics methodologies. - Universidade de Aveiro Isolation of molecules involved in high-affinity iron uptake systems of Leishmania infantum - Instituto de Biologia Molecular e Celular  IBMC The glyoxalase pathway in Leishmania: Potential therapeutical applications - Universidade de Lisboa - Fundao da Faculdade de Cincias u^6MDQJ6 '=(  Q  J      6            CH 4 0޽h ? 33___PPT10i.<St+D=' = @B +I  `X,(  , , 6bMT B Host-Parasite Interactions during the Hepatic Stages of Malaria Infections - Instituto Gulbenkian de Ciencia The effect of chloroquine on the modulation of mosquito response to Plasmodium infection - Universidade Nova de Lisboa - Instituto de Higiene e Medicina Tropical  IHMT Structural characterization of MrkD protein from Klebsiella pneumoniae : implications in the epithelial adhesion properties of the microorganism. - Universidade Nova de Lisboa - Instituto de Tecnologia Qumica e Biolgica  ITQB M%[QXM"F  P3LTM      @ Q!        L W , Bb &Projects in Pathogenomics before 2004''2      H , 0޽h ? 33___PPT10i.<+D=' = @B +  ((  (L ( 0s T   Functional genomics in malaria  an unbias RNAi screen to determine the required host cell molecules and pathways for Plasmo_|rothmrothmbio՜.+,0d    BildschirmprsentationiINSAchi|z  ArialTimes New Roman#Modelo de apresentao predefinidoFolie 1Folie 2Folie 3Foldium sporozoite fully development inside hepatocytes - Instituto de Medicina Molecular P#x 1#&    R          ( <M ") #Projects in Pathogenomics > 2004 ,$#0      H ( 0޽h ? 33___PPT10i. <`qp+D=' = @B + (  k  <pp AMicrobes: Yeasts: Analysis and identification of gene regulatory networks Helicobacter pylori: Identification of the gluconeogenic pathway enzymes used for anabolic biosynthesis in H. pylori. Neisseria meningitidis: Antibiotic resistant markers, adhesion markers and markers as potential vaccines against meningococci.B 8V g   7     =  Y      <XbgF Research Fields for the future* H  0޽h ? 33___PPT10i.: )+D=' = @B +r$0. (   e 3( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4      rM4 e)4(:( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4      r\: e8:7@( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0ppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4       (  [  <pp AMicrobes: Yeasts: Analysis and identification of gene regulatory networks Helicobacter pylori: Identification of the gluconeogenic pathway enzymes used for anabolic biosynthesis in H. pylori. Neisseria meningitidis: Antibiotic resistant markers, adhesion markers and markers as potential vaccines against meningococci.B 8V g   7     =  Y      <XbgF Research Fields for the future* H  0޽h ? 33___PPT10i.: )+D=' = @B +rk@FFeG@.L( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4      E \T (     <D, THost-microbe interaction: Cell-cell communication: Klebsiella pneumoniae Nosocomial infection: Klebsiella pneumoniae: identification of extended-spectrum beta-lactamases by genomic approach Pseudomonas aeruginosa: identification of mettalo-beta-lactamases by genomic approach JAt4                <$9 Research Fields for the future* H  0޽h ? 33___PPT10i.: )+D=' = @B +5 LD$(  $ $ B  >Host-microbe interaction: Antimicrobial resistance mechanisms (also Public health needs): Neisseria meningitidis Mycobacterium tuberculosis V A44[    $ < Research Fields for the future* H $ 0޽h ? 33___PPT10i.:LO^+D=' = @B +rjL ERWeFL[( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4      3 JB (     <D, BHost-microbe interaction: Cell-cell communication: Klebsiella pneumoniae Nosocomial infection: Klebsiella pneumoniae: identification of extended-spectrum beta-lactamases by genomic approach Pseudomonas aeruginosa: identification of mettalo-beta-lactamases by genomic approach JAt4                <$9 Research Fields for the future* H  0޽h ? 33___PPT10i.: )+D=' = @B +r\ae[%g( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` 80<'    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4TdTd B 0eppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %4      rage=g 2004 Research Fields for the future \ VA      - H @ 0޽h ? 3380___PPT10.<꧊rpmos eLmv( `/ 0DArialNew 00B 0"DTimes New Roman0B 0@ . @n?" dd@  @@`` @8@)    ,R$d_}Ω e 0AAPf@wG}L ʚ;(9ʚ;g4SdSd B 0ppp@ <4ddddLpC 00 <4BdBdLhG 080___PPT10 qq?  %P       rv ev|