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%O =D?? FORESIGHT STUDY Future Trends and Challenges in Pathogenomics,@F?D,$  .JUDITH SIMON & SVEN POMPE PROGRAMME GROUP MUT//?% OBJECTIVES  Overview on future trends and challenges in research on human-pathogenic microorganisms (bacteria & fungi) Developments in basic research Diagnostics & therapy Public health Research co-operations Technology transfer & market developmentk()k  " Q2       zQ STRUCTURE  Methods Literature & internet research Preliminary assessment Expert survey Results Research foci Methods, diagnostics & therapeutics Challenges for research Public health Co-operations Market development & technology transfer Recommendations Discussion ZDZZZ$Z]ZZD$]  h          R.METHODSTriangulation: combination of literature and internet research with expert survey & interviews "Triangulation [...] reduces the risk of systematic distortions inherent in the use of only one method. <_j`"j"`    d<METHODS: Literature Research  Databases PubMed Medline Important scientific journals Keywords & combinations pathogenomics, infectious disease, public health, bacteria, fungi, bioweapons, bioterrorism and/or human-pathogenic Focus on reviews Specialised articles on particular micro-organisms were excluded Z/ZZtZZAZ "/""t""A "              a;METHODS: Internet ResearchVInternet research on national & international Surveys Experts Institutions Networks ./(/"("P/ b9METHODS: Preliminary Assessment"  ",   Addressee: 62 members of the ERA-NET PathoGenoMics from 17 countries Questions Contact partners and national institutions National main foci in microbiological research National newly emerging hot topics in pathogenomics Existing foresight studies on pathogenomics or related subjects  ;  "'""" "  " Y"5"?"" " &   v &        oGMETHODS: Expert Survey, Development and application of questionnaires with questions on Basic research Future prospects in diagnostics & therapy Strengths and weaknesses in research Important cooperations and projects Technology transfer & market development Public health N@@"""""2           Z6METHODS: Expert Survey,  \7METHODS: Expert Survey,  VRESULTS: Research Foci  WRESULTS: Trends in Methodology   XRESULTS: Trends in Omic`s  YRESULTS: Trends in Omic`s  ZRESULTS: Trends in Diagnostics  TUse of novel technologies PCR Sequence-based identification Molecular strain typing*;;  [$RESULTS: Challenges for Therapeutics %$>   Extension of databases & discovery of molecular strategies In order to ... enable comprehensive statistical and comparative analyses standardise & validate diagnostics find novel targets develop new vaccines innovate antibiotic intervention individualise therapyB;;            \ RESULTS: Challenges for Research ! ,  {Multidisciplinary research on Ecology & environment Population dynamics Evolution & taxonomy Epidemiology Risk assessment X\\     ] RESULTS: Challenges for Research ! ,  Basic research on infection & pathogenesis Analysis of host-pathogen-interaction Identification of signaling pathways Analysis of metabolic interactions Identification of virulence factors Target identification ... X++      ^RESULTS: Public Health - Risks ZMajor risks are Multidrug resistance (cf. tuberculosis) Nosocomial infections Bioterrorism:ZKZ>       _RESULTS: Public Health Measures  ,dSurveillance systems Action plans for emergencies Vaccination strategies Rapid and early diagnosticsee      iARESULTS: Co-operations   ({S5RESULTS: Market Development & Technology Transfer66 Barriers High R&D costs Limited market size for vaccines and antibiotic products compared to the market for diseases of civilisation& | |    ~Opportunities Public-private partnerships Subcontracting with SME`s for preclinical studies Public funding for orphan drugs 6nn  X4RECOMMENDATIONSz1. Establish a European surveillance system 2. Reduce the misuse of pesticides in agriculture and animal technology 3. Create a European Competence Center for epidemiological research and modelling 4. Create an R&D programme that is specifically tailored to support public-private partnerships 5. Create structures for early warning and rapid response to emergencies {Z"*"""G" " "P"""`"" " I " $"$((, '       - b K mERECOMMENDATIONS6. Develop comparative risk assessment strategies for setting national health priorities 7. Reconsider work-sharing between research institutes and universities 8. Foster cooperations between microbiological researchers and clinicians 9. Foster inclusion of ecological aspects into microbiology 10. Improve transparency about the function of different networks on pathogenomics 11. Conduct a study on industrial research objectives and economic interestsZ"X"""G" " "I""";"" " P " $"$L$"$((Z I     4 = G       `  THANK YOU VERY MUCH FOR YOUR ATTENTION! The complete report on FUTURE TRENDS AND CHALLENGES IN PATHOGENOMICS will soon be available at http://www.pathogenomics-era.net@Z*b!t/:  aRECOMMENDATIONSE1. Establish a European surveillance system 2. Reduce the misuse of pesticides in agriculture and animal technology 3. Create a European Competence Center for epidemiological research and modelling 4. Create an R&D programme that is specifically tailored to support public-private partnerships 5. Create structures for early warning and rapid response to emergencies 6. Develop comparative risk assessment strategies for setting national health priorities 7. Reconsider work-sharing between research institutes and universities 8. Foster cooperations between microbiological researchers and clinicians 9. Foster inclusion of ecological aspects into microbiology 10. Improve transparency about the function of different networks on pathogenomics 11. Conduct a study on industrial research objectives and economic interests FZ"*"""F" " "O"""_"" " H "  " X " $"$("(F("(,",0"00"0G4"48"8:8"8<"<"P""N", H    , a  H     < G       /~      ` ` ̙33` 333MMM` ff3333f` f` f` 3>?" dd@ |?" dd@   " @ ` n?" dd@   @@``PR    @ ` ` p>>  (    6 P  a-Klicken Sie, um das Titelformat zu bearbeiten. .4  0   pKlicken Sie, um die Formate des Vorlagentextes zu bearbeiten Zweite Ebene Dritte Ebene Vierte Ebene Fnfte Ebene=     q  0  P   5    0l `   \*B    f_ж_жDV?"H  0޽h ? ̙33 Standarddesign 0 P<((  < < 0P P    P*   < 0     R*  d < c $ ?  4 < 0d  @  pKlicken Sie, um die Formate des Vorlagentextes zu bearbeiten Zweite Ebene Dritte Ebene Vierte Ebene Fnfte Ebene=     q < 6 `P   P*   < 6h `   R*  H < 0޽h ? ̙3380___PPT10.#6 d(  d d 0"X P   X X*  d 08'X    X Z*  d 6+X `P  X X*  d 6P0X `  X Z* H d 0޽h ? ̙3380___PPT10.#6pj 0(  r  S lp  r  C JA2DIN-A1-rechts-blau-weiss v8r  S m0   H  0޽h ? ̙33  "(    c $0`p<$D 0    N <$D 0   H  0޽h ? ̙33___PPT10x.+QD' = @B D' = @BA?%,( < +O%,( < +D{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*k%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*kD' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*kD{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*l%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*lD' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*lD{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*D{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*D{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*D{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*+8+0+ +_  (    c $\`p<$D 0    N\    H  0޽h ? ̙33 ___PPT10.+ SyD' = @B DD' = @BA?%,( < +O%,( < +D{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*+8+0+ +  L(  x  c $    NX       f_ж_ж ?" `  F Maxwell 1998 (2 H  0޽h ? ̙33y___PPT10Y+D=' = @B +$  \(  \ \ c $+<$D 0   \ N,    H \ 0޽h ? ̙336"."___PPT10".+'D!' = @B Di!' = @BA?%,( < +O%,( < +D' =%(D' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*\ %(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*\ D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*\ D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*\ %(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*\ D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*\ D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*\%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*\D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*\D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*\9%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*\9D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*\9DN' =%(D' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*\9Q%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*\9QD' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*\9QD' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*\Q%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*\QD' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*\QDN' =%(D' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*\%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*\D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*\D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*\%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*\D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*\+8+0+\ +k  X(  X X c $A<$D 0   X NB    H X 0޽h ? 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̙33#!!___PPT10 .+QD ' = @B DV ' = @BA?%,( < +O%,( < +D{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*@%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*@D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*@D{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*@O%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*@OD' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*@OD{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*Oy%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*OyD' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*OyD{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*y%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*yD' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*yD{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*D{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*D{' =%(D#' =%(D' =A@BBBB0B%(D' =1:Bvisible*o3>+B#style.visibility<*%(D' =+4 8?dCB0-#ppt_w/2BCB#ppt_xB*Y3>B ppt_x<*D' =+4 8?\CB#ppt_yBCB#ppt_yB*Y3>B ppt_y<*+8+0+ +  D<` @(  @ @ N~      @  `_ж_жA ?"r T  @  f _ж_ж ?" 0 2A total of 329 experts was selected and contacted.3(23> H @ 0޽h ? 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