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Researchers Database

You have entered the IISP: Interactive Information System on Pathogenomics


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Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .


The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
  • Potential cooperation topics suggested by the researcher

If you have any comments/questions or if you would like to add some information, please contact

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Name: Dr. Darfeuille-Michaud, Arlette
City: Zip:
Country: France Phone:


Research Topics:
Cellular microbiology, adherent-invasive Escherichia coli, enterohemorragic E. coli EHEC, virulence factors, inflammatory bowel disease, Crohn’s disease, probiotics, gene regulation, bacterial invasion, bacterial adhesion, intestinal epithelial cells, macrophages. Our research group is involved in studies of pathogenic E. coli involved in inflammatory bowel diseases in humans (Crohn’s disease) or in haemorrhagic colitis and haemolytic uraemic syndrome. Cellular and molecular microbiology studies are performed to analyze the virulence factors of pathogenic bacteria and the response of intestinal epithelial cells or macrophages to infection.


Organisms studied:
  • EHEC
  • EIEC
  • Escherichia coli


Special methods / technologies:
Caracterization of virulence genes and regulatory pathways. Adhesion to and invasion of various differentiated or non differentiated intestinal epithelial cells. Interaction of bacteria with human isolated primary enterocytes. Intracellular replication and traffic of intracellular bacteria within murine and human macrophages. Cellular models to study the role of TLR and NOD receptors in intestinal epithelial cells and macrophages to bacterial infection. Animal models of experimental colitis.


Suggestions for potential research cooperations:
Identification of virulence genes specific to E. coli colonizing the intestinal mucosa of patients with Crohn’s disease or ulcerative colitis.
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