You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to email@example.com or firstname.lastname@example.org.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
If you have any comments/questions or if you would like to add some information, please contact email@example.com
|1)Elucidation of the conjugative plasmid transfer mechanisms of Gram-positive pathogenic bacteria: The mechanism seems to be related to the type IV protein secretion mechanism responsible for effector/toxin transfer from Gram-negative pathogenic bacteria to eukaryotic hosts and effective in conjugative plasmid transfer in Gram-negative bacteria. Model plasmid of our studies is the multiple antibiotic resistance plasmid pIP501 with the broadest known host range for a plasmid originating from Gram-positive bacteria known until now. A protein-protein interaction map of the transfer proteins was established and all transfer proteins are supplied to biochemical/biophysical analysis and 3D structure solution. Model organisms are Enterococcus faecalis and Streptococcus pneumoniae. 2) Protein-protein interaction studies between Enterococcus faecalis virulence proteins/surface-associated proteins with human proteins to elucidate key protein-protein interactions effective in Enterococcus pathogenesis. Identified targets are evaluated with respect to use as potential drug targets.|
|Special methods / technologies:|
|yeast two-hybrid assay, automated yeast two-hybrid screening (HT) Protein crystallography, SAXS, CD-spectroscopy|
|Suggestions for potential research cooperations:|
|3D-structural analysis of proteins involved in conjugation and protein secretion|