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Researchers Database

You have entered the IISP: Interactive Information System on Pathogenomics


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Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .


The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
  • Potential cooperation topics suggested by the researcher

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Name: Prof. Dr. Dr. Podbielski, Andreas
Address: Schillingallee 70
Institution: Universität Rostock, Institut für Medizinische Mikrobiologie und Hygiene
City: Rostock Zip: D-18055
Country: Germany Phone: +49-38/494 5900
    Fax: +49-38/494 5902


Research Topics:
1. Streptococcus pyogenes a) structure and function (e.g. localization of modules, quantitation of specific activities) of virulence factors (e.g. fibronectin-/collagen-binding adhesins/internalins) b) characterization (e.g. appropriate mutants, reporter gene tags, EMSA) of regulators (e.g. stand-alone r., two component systems) and regulatory pathways (e.g. transcriptome / proteome analyses, determination of complex biological functions) c) characterization of genomic virulence regions / islands (e.g. differential expression by alternative signal peptidases, sortases) d) mechanisms of long-term survival and intracellular persistence e) quantitation of S. pyogenes in patient material gained from prospective interdisciplinary clinical studies, molecular epidemiology of specific genes, in vivo gene expression 2. Oral ecology in S. pyogenes and viridans streptococcal mono- and oligospecies biofilms a) temporal development of biofilms, quantitation by viable and in situ counts, examination of ultrastructure by electron / confocal laser scan microscopy b) flow cell and transwell chamber techniques c) identification of S. pyogenes genes involved in biofilm behavior d) potential alteration of S. pyogenes biological functions (protein/eukaryotic cell interactions, hemolytic activity, production of secreted virulence factors) e) S. pyogenes transcriptome upon contact with viridans streptococci f) selection of potential probiotic viridans streptococci, bacteriocins, and phages for a therapeutic influence on the presence and persistence of S. pyogenes in oral biofilms


Organisms studied:
  • alpha-hemolytic streptococci
  • Anginosus-group streptococci
  • Staphylococcus
  • streptococci (Viridans group)
  • Streptococcus dysgalactiae
  • Streptococcus pyogenes


Special methods / technologies:
biofilm culture techniques, electron / confocal laser scan microscopy, FISH / GFP-tags, quantitative protein-protein-interactions (surface plasmon resonance), bacteria-eukaryotic cell interactions (adherence/internalization processes), complex mutations in streptococci, reporter gene tags, transcriptomics by RT-PCR & arrays, proteomics


Suggestions for potential research cooperations:
establishment of precise data on S. pyogenes persistence in recurrently infected tissues with ENT-specialists,
in vitro testing of potentially probiotic bacteria in cooperation with pharmaceutical companies
in vivo studies on the ap
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