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External Advisory Board Member Spain

Prof. Dr. Francisco García-del Portillo

Dep. Biotechnología Microbiana
Centro Nacional de Biotechnología
Campus de Cantoblanco
ES-28049 Madrid




My group studies at a molecular level host-pathogen interactions between intracellular bacterial pathogens and eukaryotic cells . Using the Gram-negative pathogen Salmonella as a model, we investigate the regulatory circuits that modulate the bacterial replication rate within the infected host cell. Genome-wide expression analyses are used to identify key factors, of both pathogen and host cell origin, which control growth, persistence or killing of intracellular Salmonella . Proteomics techniques are also applied to identify novel cell-surface proteins of the Gram-positive pathogen Listeria required for colonization of host eukaryotic cell.


Our laboratory of ‘Microbial Pathogenesis' is located in the Department of Microbial Biotechnology at the National Center for Biotechnology (CNB) ( . This Centre belongs to the ‘Consejo Superior de Investigaciones CientÌficas (CSIC)' ( , the Spanish Government Institution for Research.



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