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Researchers Database

You have entered the IISP: Interactive Information System on Pathogenomics


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Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .


The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
  • Potential cooperation topics suggested by the researcher

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Name: PD Dr. Guzman, Carlos A.
Address: Inhoffenstrasse 7
38124 Braunschweig
Institution: Helmholtz Centre of Infection Research, Department of Vaccinology
City: Braunschweig Zip: D-38124
Country: Germany Phone: +49-531/6181558
    Fax: +49-531-618141120


Research Topics:
The main goal of our research group is the development of new immunization strategies to optimize the immune responses stimulated following mucosal vaccination. To this end, we identify and characterize protective antigens, adjuvants and delivery systems for DNA- and/or proteins. The genome of the environmental strain Bordetella petrii was sequenced and annotated. Subsequent comparative genome analysis with the pathogenic members of this genus has allowed the identification of new virulence factors, critical metabolic pathways, and genes responsible for host tropism. This knowledge is helping us to generate attenuated derivatives of B. bronchiseptica able to stimulate protective immune responses against infections, which would be also exploited as carriers for heterologous antigens. This is facilitated by the development of new animal models based on transgenic and humanized mice.


Organisms studied:
  • Bordetella
  • HBV
  • HCV
  • HIV
  • Streptococci


Special methods / technologies:
immunogenicity and efficacy studies in mice (conventional, transgenic, humanized mice); micro array; ELISPOT; Cytometric Beat Array; Luminex; in vivo CTL; monitoring of humoral and cellular immune responses at systemic and mucosal level; homing and memory; adoptive transfer of immune cells; annotation


Suggestions for potential research cooperations:
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