You have entered the IISP: Interactive Information System on Pathogenomics
If you would like to insert information about your research or research group, please click to the following link to download the form. After filling it out, please send back to email@example.com or firstname.lastname@example.org.
Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .
The following information is available and can be searched for:
- researcher names
- Institution of the respective researcher, city and country of his/her institution
- Contact data of the researcher (address, phone, email)
- Research topics and studied microorganisms of the researcher
- Special techniques applied by the researcher
- Potential cooperation topics suggested by the researcher
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|Name:||PD Dr Niemann, Stefan|
|Address:||Molecular Mycobacteriologie Group, Research Center Borstel Parkallee 1, 23845 Borstel, Germany|
|Institution:||Research Center Borstel|
|Main research interests of the group are focused on the analysis of the epidemiology of tuberculosis (TB) by applying molecular epidemiological tools, on the analysis of the global population structure, genomic diversity and virulence of M. tuberculosis complex (MTBC) strains, and on the investigation of molecular determinants and microevolution of resistant strains. In recent years, we have carried out several studies on the epidemiology of TB in different settings that provided e.g. for the first time precise data on transmission dynamics of MTBC strains in Germany. Future epidemiological studies will be focused on highly relevant research questions e.g. the analysis of pathogenic properties specific for strains of particular phylogenetic lineages such as a higher virulence or an enhanced propensity to acquire drug resistance. The initiation of studies in high incidence countries with a focus on Eastern Europe is intended. All strains will be archived and provide a unique bio bank for future research studies. Actual research focuses on the analysis of the global population structure, genomic diversity and virulence of MTBC . Here we analyze the genetic diversity of MTBC strains by modern tools of bacterial genomics such as comparative genome, transcriptome and proteome analyses. Knowledge on the genetic diversity of clinical isolates will be linked with differential modulation of the disease by analysis of selected strains in infection model systems. A field of extraordinary importance is the analysis of molecular determinants and microevolution of resistant strains. The investigation of resistance mechanisms of clinical M. tuberculosis isolates has long been a main focus of research that will be continued and intensified. In addition to classical analysis methods, new tools for comparative genomics such as ultra fast massively parallel genome sequencing will be used to decipher new resistance mechanisms. Furthermore, we will investigate the microevolution in resistant MTBC strains to identify evolutionary changes compensating for cumulative fitness costs of combined drug resistance mutations.|
|Special methods / technologies:|
|Genotyping of M. tuberculosis complex isolates by: IS6110-DNA-Fingerprint, Spoligotyping, MIRU-VNTR typing Gene expression analysis of M. tuberculosis complex isolates by: Real-Time PCR, Whole genome expression profiling Bioinformatic analysis and storage of typing data by using the Bionumerics software Bioinformatic analysis of DNA sequence data by using different software packages (SeqScape, Lasergene, GenDB)|
|Suggestions for potential research cooperations:|