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Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .


The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
  • Potential cooperation topics suggested by the researcher

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Name: Dr. Werner, Guido
Institution: Robert Koch Institute Wernigerode, FG 13 Nosocomial Infections
City: Wernigerode Zip: 38855
Country: Germany Phone: +49 3943 679 210
    Fax: +49 3943 679 207


Research Topics:
- antibiotic resistance and virulence in bacteria (emergence and spread) - molecular mechanisms of antibiotic resistance and pathogenicity - molecular diagnostics - molecular epidemiology - population biology in bacteria - Main research intetests are in the molecular background, the evolution and ways of dissemination of mechanisms of antibiotic resistance in bacteria. Bacteria in focus are nosocomial pathogens and opportunistic nosocomial bacteria such as Enterococcus (E. faecalis/faecium), Staphylococcus aureus, Clostridium difficile and members of the Enterobacteriaceae (E. coli, Enterobacter spp., Citrobacter spp., Klebsiella spp.,). Resistance traits of greatest interest are: (1) methicillin resistance in S. aureus, vancomycin resistance in Enterococcus, ESBL-mediated (Extended-spectrun beta-lactamase) resistance in Enterobacteriaceae. Questions to be answered in a population-based approach are to distinguish between commensal and pathogenic lineages within the same species or identify ways of emergence and spread of pathogenicity and resistance markers, islets and islands within these species.


Organisms studied:
  • Citrobacter
  • Clostridium difficile
  • Enterobacter
  • Enterococcus faecalis
  • Enterococcus faecium
  • Escherichia coli
  • Klebsiella pneumoniae
  • Staphylococcus


Special methods / technologies:
Basic phenotypic tests for antimicrobial susceptibility testing (MIC) and species identification via sugar fermentation panels and specific reactions. Baisc molecular techniques like (1) genomic and plasmid DNA isolation from bacteria, transformation into and transconjugation between bacteria, PCR, Real-time PCR, sequencing, hybridization techniques, DNA array technology. Several typing techniques such as: (1) Macrorestriction analysis in PFGE (pulsed-field gel electrophoresis); (2) MLVA (Multiple locus variable number of tandem repeat analysis), (2) MLST (Multi-locus sequence typing); (4) AFLP (Amplified fragment length polymorphism). Software for an evaluation of typing results.


Suggestions for potential research cooperations:
Interest in any research cooperation in the field of hospital- or/and ambulatory-acquired bacterial infections in man (staphylococci, enterococci, E. coli, Klebsiella spp., Enterobacter spp., Clostridium difficile). In addition, ecological studies addressing the fact that certain bacteria are capable to reside as commensal (animal and human), environmental and opportunistic pathogen are of interest. Main focus would be on (1) population biology (comparison of commensal vs. pathogenic clonal lineages in a genome-wide approach); (2) Emergence and spread of so-called super-bugs (MRSA, VRE, multi-resistant gram-negative bacteria), (3) Evolution of antibiotic resistance islands and pathogenic islands and islets; (4) Environmental factors influencing dissemination of those bacteria (antibiotic regimen inside/outside hospitals, role of vaccination, role of standard infection control procedures, etc.).
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