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Researchers Database

You have entered the IISP: Interactive Information System on Pathogenomics


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Here you will find information about Research groups in the PathoGenoMics fields from the ERA-NET partner countries (Austria, Finland, France, Hungary, Israel, Latvia, Portugal, Slovenia and Spain).
This information is supposed to support cooperation between researchers from different European countries
and thus enhance the development of a European Research Area for PathoGenoMics .


The following information is available and can be searched for:

  • researcher names
  • Institution of the respective researcher, city and country of his/her institution
  • Contact data of the researcher (address, phone, email)
  • Research topics and studied microorganisms of the researcher
  • Special techniques applied by the researcher
  • Potential cooperation topics suggested by the researcher

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Name: Dr. Guiso, Nicole
Address: 25 rue du Dr Roux
Institution: Institut Pasteur, Unité Prévention et Thérapie des Maladies humaines
City: PARIS Zip: 75015
Country: France Phone: 01 45 68 83 34


Research Topics:
Vaccination is one of the most successful tools for controling infectious diseases. Although it is generally perceived as the ”golden solution”, it has been shown recently that the extensive use of vaccines may lead to undesirable effects (e.g. poliomyelitis epidemics due to vaccine-derived viruses) or the resurgence of a disease (e.g. re-emergence of whooping cough after 40 years of vaccination). In the documented cases, epidemiological studies clearly indicate that extensive vaccinations can induce modifications of the pathogens over time, the emergence of new pathogens due to changes in the ecosystems, or change in the transmission of the disease. Therefore, to optimise the benefits of immunization programs and prevent new global adverse effects of vaccines (and the subsequent detrimental impact in the general public), the consequences of extensive vaccinations on the pathogen, ecosystem and/or human host populations remain to be evaluated. In this context, the main objective of this unit is to evaluate the consequences of extensive vaccination in human and microbial populations, and to propose adapted strategies of prevention and new therapeutic tools in order to face some of these consequences. Our unit also harbors the National Center of Reference for Whooping Cough and Other Bordetellosis.


Organisms studied:
  • Bordetella
  • Enterobacteriaceae


Special methods / technologies:
PFGE, Microarrays, Real Time PCR, Immunochemical techniques, Murine model, Cellular models.


Suggestions for potential research cooperations:
Bacterial population genetics, Vaccine preventable Diseases, Development of therapies
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